C57BL/6JCya-Oxr1em1/Cya
Common Name:
Oxr1-KO
Product ID:
S-KO-18866
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Oxr1-KO
Strain ID
KOCMP-170719-Oxr1-B6J-VA
Gene Name
Product ID
S-KO-18866
Gene Alias
2210416C20Rik; C7; C7B
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
15
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Oxr1em1/Cya mice (Catalog S-KO-18866) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000110297
NCBI RefSeq
NM_001130166
Target Region
Exon 4
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
Oxr1, or Oxidation Resistance 1, is a highly conserved gene belonging to the TLDc domain-containing family. It is involved in multiple fundamental biological and cellular processes such as DNA damage response, antioxidant pathways, cell cycle, neuronal protection, and arginine methylation [3].
In Drosophila, knockdown of mtd (the fly homolog of OXR1) in adulthood inhibits dietary-restriction-mediated lifespan extension in female flies. Loss of mtd/OXR1 destabilizes the retromer, causing improper protein trafficking and endolysosomal defects, while overexpression of retromer genes or pharmacological restabilization can rescue lifespan and neurodegeneration in mtd-deficient flies [1]. In mice, lack of Oxr1 leads to cerebellar neurodegeneration, and over-expression makes neurons less susceptible to exogenous stress. A conserved short isoform of Oxr1 also confers neuroprotective property in vitro and in vivo [2]. In human patient-derived cells, a loss-of-function mutation in OXR1 impairs cell survival, proliferation, neural differentiation, and causes hypersensitivity to oxidative stress [3].
In conclusion, Oxr1 plays a crucial role in maintaining retromer function, protecting neurons from oxidative-stress-induced neurodegeneration, and is involved in neurodevelopment. The study of Oxr1 using gene knockout models in flies and mice, as well as patient-derived cell models, has provided insights into its function in aging-related processes and neurodegenerative diseases, offering potential therapeutic targets for these conditions.
References:
1. Wilson, Kenneth A, Bar, Sudipta, Dammer, Eric B, Ellerby, Lisa M, Kapahi, Pankaj. 2024. OXR1 maintains the retromer to delay brain aging under dietary restriction. In Nature communications, 15, 467. doi:10.1038/s41467-023-44343-3. https://pubmed.ncbi.nlm.nih.gov/38212606/
2. Oliver, Peter L, Finelli, Mattéa J, Edwards, Benjamin, Davies, Ben, Davies, Kay E. 2011. Oxr1 is essential for protection against oxidative stress-induced neurodegeneration. In PLoS genetics, 7, e1002338. doi:10.1371/journal.pgen.1002338. https://pubmed.ncbi.nlm.nih.gov/22028674/
3. Lin, Xiaolin, Wang, Wei, Yang, Mingyi, Ye, Jing, Bjørås, Magnar. 2023. A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment. In Genome biology, 24, 216. doi:10.1186/s13059-023-03037-1. https://pubmed.ncbi.nlm.nih.gov/37773136/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen