C57BL/6JCya-Il36gem1/Cya
Common Name:
Il36g-KO
Product ID:
S-KO-18884
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Il36g-KO
Strain ID
KOCMP-215257-Il36g-B6J-VB
Gene Name
Product ID
S-KO-18884
Gene Alias
IL-36gamma; If36g; Il1f9
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Il36gem1/Cya mice (Catalog S-KO-18884) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000057567
NCBI RefSeq
NM_153511
Target Region
Exon 4
Size of Effective Region
~0.1 kb
Detailed Document
Overview of Gene Research
Il36g, also known as interleukin 36 gamma, is a cytokine that plays a significant role in immune-related biological processes. It is involved in inflammatory responses and is associated with pathways such as the IL-23/IL-17 axis, which is crucial in psoriasis pathology [4].
In psoriasis, studies have shown various relationships related to Il36g. The expression of Il36g in keratinocytes follows an inverse pattern to that of PCSK9, with Il36g expression highest in granular layer keratinocytes [1]. Genetic variants of Il36g are associated with psoriasis susceptibility, severity, and joint involvement. For example, the G allele of the Il36g rs7584409 variant has a protective effect against psoriasis, but in patients with psoriasis, it is associated with moderate-to-severe disease and psoriatic arthritis [3]. Polymorphisms in the Il36g gene are also associated with plaque psoriasis, potentially affecting the functionality of the IL-36γ cytokine [4].
In cancer, IL36G-producing neutrophil-like monocytes, called cachexia-inducible monocytes (CiMs), promote skeletal muscle loss in cachexia, and genetic inhibition of IL36G-mediated signaling attenuates this muscle loss [2].
In conclusion, Il36g is a cytokine with a notable role in inflammatory and immune-related processes, especially in diseases like psoriasis and cancer cachexia. Studies on Il36g, including those using genetic models to understand its variants and functions, have provided insights into the pathogenesis of these diseases, which may help in developing new therapeutic strategies for these conditions.
References:
1. Merleev, Alexander, Ji-Xu, Antonio, Toussi, Atrin, Gudjonsson, Johann E, Maverakis, Emanual. 2022. Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G. In JCI insight, 7, . doi:10.1172/jci.insight.141193. https://pubmed.ncbi.nlm.nih.gov/35862195/
2. Hayashi, Yoshihiro, Kamimura-Aoyagi, Yasushige, Nishikawa, Sayuri, Harada, Yuka, Harada, Hironori. 2024. IL36G-producing neutrophil-like monocytes promote cachexia in cancer. In Nature communications, 15, 7662. doi:10.1038/s41467-024-51873-x. https://pubmed.ncbi.nlm.nih.gov/39266531/
3. Moreira, Cássio Rafael, de Alcântara, Camila Cataldi, Flauzino, Tamires, Reiche, Edna Maria Vissoci, Simão, Andréa Name Colado. 2023. IL36G genetic variant is independently associated with susceptibility, severity and joint involvement in psoriasis. In Molecular immunology, 159, 69-75. doi:10.1016/j.molimm.2023.05.010. https://pubmed.ncbi.nlm.nih.gov/37285630/
4. Traks, Tanel, Keermann, Maris, Prans, Ele, Kõks, Sulev, Kingo, Külli. 2019. Polymorphisms in IL36G gene are associated with plaque psoriasis. In BMC medical genetics, 20, 10. doi:10.1186/s12881-018-0742-2. https://pubmed.ncbi.nlm.nih.gov/30634937/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen