C57BL/6JCya-Mvpem1/Cya
Common Name
Mvp-KO
Product ID
S-KO-18939
Backgroud
C57BL/6JCya
Strain ID
KOCMP-78388-Mvp-B6J-VB
Status
When using this mouse strain in a publication, please cite “Mvp-KO Mouse (Catalog S-KO-18939) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Mvp-KO
Strain ID
KOCMP-78388-Mvp-B6J-VB
Gene Name
Product ID
S-KO-18939
Gene Alias
LRP, VAULT1, 2310009M24Rik
Background
C57BL/6JCya
Gene Full Name
major vault protein
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 7 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000165096
NCBI Transcript ID
NM_080638
Target Region
Exon 2~3
Size of Effective Region
~1.5 kb
Overview of Gene Research
Major Vault Protein (MVP), the main structural protein of the vault complex, is involved in various biological processes. It has been shown to play a role in apoptosis, prevention of metabolic diseases in macrophages, and is associated with multiple signaling pathways such as JAK2-STAT6, calcineurin-NFATc1, and Fas-mediated apoptosis pathways [1,2,3]. Genetic models like Mvpflox/floxLyz2-Cre (myeloid-specific MVP gene knockout, MacKO) and Mvp-/-(total body MVP gene knockout) mice are crucial for studying its functions.
In macrophages, the lack of MVP impairs their transition from a pro-inflammatory to an anti-inflammatory phenotype during fracture repair. This leads to increased secretion of pro-inflammatory cytokines, promoting osteoclastic differentiation and impairing BMSC osteogenic differentiation, ultimately resulting in impaired fracture repair in MacKO mice [1]. In osteoclasts, MVP-deficient mice (Mvp-/-and Mvpf/fLyz2-Cre) exhibit osteoporosis-like phenotypes, as MVP deficiency enhances calcineurin-NFATc1 signaling, promoting osteoclastogenesis and bone resorption [2]. Also, conditional knockout of MVP in monocyte lineage (Mvpf/fLyz2-Cre mice) inhibits osteoclast apoptosis in aging and estrogen-deficiency-related osteoporosis contexts [3].
In conclusion, MVP has immunomodulatory, anti-osteoclastogenic, and pro-osteoclast apoptosis functions. The gene knockout mouse models have significantly contributed to understanding its roles in fracture repair and osteoporosis, providing potential therapeutic targets for these bone-related diseases [1,2,3].
References：
1. Yang, Yan, Zhao, Na, Wang, Ruobing, Ben, Jingjing, Ma, Junqing. 2023. Macrophage MVP regulates fracture repair by promoting M2 polarization via JAK2-STAT6 pathway. In International immunopharmacology, 120, 110313. doi:10.1016/j.intimp.2023.110313. https://pubmed.ncbi.nlm.nih.gov/37267856/
2. Yuan, Lichan, Zhao, Na, Wang, Junyi, Ben, Jingjing, Ma, Junqing. 2021. Major vault protein (MVP) negatively regulates osteoclastogenesis via calcineurin-NFATc1 pathway inhibition. In Theranostics, 11, 7247-7261. doi:10.7150/thno.58468. https://pubmed.ncbi.nlm.nih.gov/34158848/
3. Wang, Ruobing, Yang, Yan, Zhang, Zhongyin, Ma, Junqing, Yuan, Lichan. 2023. Major vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts. In Cell death & disease, 14, 604. doi:10.1038/s41419-023-05928-4. https://pubmed.ncbi.nlm.nih.gov/37704623/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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