C57BL/6JCya-Cenplem1/Cya
Common Name:
Cenpl-KO
Product ID:
S-KO-18955
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Cenpl-KO
Strain ID
KOCMP-70454-Cenpl-B6J-VA
Gene Name
Product ID
S-KO-18955
Gene Alias
2610300B10Rik; CENP-L
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
1
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cenplem1/Cya mice (Catalog S-KO-18955) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000111620
NCBI RefSeq
NM_001159930
Target Region
Exon 4
Size of Effective Region
~0.5 kb
Detailed Document
Overview of Gene Research
Cenpl, short for Centromere protein L, is an important member of the centromere protein (CENP) family. It is involved in the mitotic process of eukaryotic cells, playing a crucial role in cell division. Although the specific associated pathways are not comprehensively detailed in the provided references, its significance in cell-cycle-related processes is emphasized [1,4].
Cenpl has been found to be upregulated in most cancers, including lung adenocarcinoma (LUAD), pancreatic adenocarcinoma (PAAD), breast cancer, and hepatocellular carcinoma (HCC) [1-7, 9]. In LUAD, its upregulation and mutation are associated with a poorer prognosis, and it regulates cell proliferation, cell cycle, and is negatively correlated with the inflammation level and CD8+ T-cell infiltration [1]. In breast cancer, high Cenpl expression is related to cell cycle-associated processes, immune cell infiltration, and knockdown of Cenpl reduces cell proliferation and migration [3]. In HCC, Cenpl promotes cell proliferation, cell cycle progression, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway, and serves as an independent prognostic factor [4]. In PAAD, overexpression of Cenpl mRNA is significantly correlated with poor prognosis [2].
In conclusion, Cenpl is essential for the mitotic process in eukaryotic cells. Through studies on cancer models, it has been revealed that Cenpl plays a significant role in the development and prognosis of multiple cancers, making it a potential biomarker and therapeutic target for cancer treatment [1-7, 9].
References:
1. Feng, Ziyang, Chen, Yu, Cai, Changjing, Zeng, Shan, Han, Ying. 2022. Pan-Cancer and Single-Cell Analysis Reveals CENPL as a Cancer Prognosis and Immune Infiltration-Related Biomarker. In Frontiers in immunology, 13, 916594. doi:10.3389/fimmu.2022.916594. https://pubmed.ncbi.nlm.nih.gov/35844598/
2. Cui, Zhongyuan, Du, Ling, Wang, Jielong, Chen, Gang, Wu, Zhixian. 2022. Overexpression of CENPL mRNA potentially regulated by miR-340-3p predicts the prognosis of pancreatic cancer patients. In BMC cancer, 22, 1354. doi:10.1186/s12885-022-10450-5. https://pubmed.ncbi.nlm.nih.gov/36572856/
3. Gui, Zhengwei, Tian, Yao, Liu, Shiyang, Liu, Chenguang, Zhang, Lin. 2023. Highly expressed CENPL is correlated with breast cancer cell proliferation and immune infiltration. In Frontiers in oncology, 13, 1046774. doi:10.3389/fonc.2023.1046774. https://pubmed.ncbi.nlm.nih.gov/36816951/
4. He, Kun, Xie, Mengyi, Hong, Weifeng, You, Chuan, Li, Jingdong. 2023. CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma. In The international journal of biochemistry & cell biology, 166, 106481. doi:10.1016/j.biocel.2023.106481. https://pubmed.ncbi.nlm.nih.gov/37914022/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen