C57BL/6JCya-Tns1em1/Cya
Common Name
Tns1-KO
Product ID
S-KO-18974
Backgroud
C57BL/6JCya
Strain ID
KOCMP-21961-Tns1-B6J-VA
When using this mouse strain in a publication, please cite “Tns1-KO Mouse (Catalog S-KO-18974) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tns1-KO
Strain ID
KOCMP-21961-Tns1-B6J-VA
Gene Name
Product ID
S-KO-18974
Gene Alias
1110018I21Rik, 1200014E20Rik, E030018G17Rik, E030037J05Rik, Tns
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000169786
NCBI RefSeq
NM_027884
Target Region
Exon 16
Size of Effective Region
~0.8 kb
Overview of Gene Research
Tns1, also known as tensin 1, is a member of the tensin family of cellular-adhesion constituents. It engages in multiple biological processes such as cell adhesion, polarization, migration, invasion, proliferation, apoptosis, and mechano-transduction by interacting with various partner proteins. The abnormal expression of Tns1 is associated with the development of various diseases, especially tumors [1].
In Tns1-knockout mice, they develop cystic kidneys and die from renal failure. Tns1-knockout MDCK cells form cysts with multiple lumens and have upregulated Mek/Erk activities. Re-expression of wild-type Tns1 can rescue this phenotype, and treatment with the Mek inhibitor trametinib can reduce interstitial infiltrates, fibrosis, and dilated tubules in Tns1-knockout kidneys, indicating Tns1's role in suppressing Mek/Erk signaling and maintaining lumenogenesis [2].
In conclusion, Tns1 is crucial for normal cell functions and is involved in various biological processes. The Tns1-knockout mouse model has revealed its significance in preventing cystic kidney diseases by suppressing the Mek/Erk pathway. Additionally, its abnormal expression is related to tumor development, highlighting its importance in understanding disease mechanisms [1,2].
References：
1. Wang, Zhihui, Ye, Jingxue, Dong, Fengrui, Wang, Min, Sun, Guibo. 2022. TNS1: Emerging Insights into Its Domain Function, Biological Roles, and Tumors. In Biology, 11, . doi:10.3390/biology11111571. https://pubmed.ncbi.nlm.nih.gov/36358270/
2. Wu, Zong-Ye, Chiu, Chun-Lung, Lo, Ethan, Yamada, Soichiro, Lo, Su Hao. 2019. Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases. In Cell death & disease, 10, 871. doi:10.1038/s41419-019-2119-7. https://pubmed.ncbi.nlm.nih.gov/31740667/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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