C57BL/6JCya-Btbd17em1/Cya
Common Name:
Btbd17-KO
Product ID:
S-KO-18975
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Btbd17-KO
Strain ID
KOCMP-72014-Btbd17-B6J-VB
Gene Name
Product ID
S-KO-18975
Gene Alias
1500005I02Rik; Tango10a
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Btbd17em1/Cya mice (Catalog S-KO-18975) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000000206
NCBI RefSeq
NM_028055
Target Region
Exon 2~3
Size of Effective Region
~4.1 kb
Detailed Document
Overview of Gene Research
Btbd17, whose specific function, associated pathways, and biological importance are yet to be fully elucidated. However, its study could potentially be enhanced through genetic models such as gene knockout (KO) or conditional knockout (CKO) mouse models for in-depth functional studies.
In a study analyzing the effects of hepatitis B virus X protein (HBx) on H3K9me3 enrichments in hepatoma cells, Btbd17 was among the 25 gene promoters whose H3K9me3 enrichments were significantly altered in hepatoma cells transfected with an HBx-expressing plasmid. Specifically, it was one of the genes with an altered H3K9me3 enrichment pattern, suggesting its possible involvement in the molecular events influenced by HBx in hepatocellular carcinoma (HCC) [1].
In conclusion, although much remains to be discovered about Btbd17, the finding that its promoter's H3K9me3 enrichment is affected by HBx in hepatoma cells indicates its potential significance in HCC-related biological processes. The use of genetic models like KO or CKO mouse models could further clarify its role in this and potentially other disease conditions.
References:
1. Wang, Di-Yi, An, Shu-Hong, Liu, Lei, Zhu, Rong, Wang, Zhao-Jin. . Hepatitis B virus X protein influences enrichment profiles of H3K9me3 on promoter regions in human hepatoma cell lines. In Oncotarget, 7, 84883-84892. doi:10.18632/oncotarget.12751. https://pubmed.ncbi.nlm.nih.gov/27768594/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen