C57BL/6JCya-Orm1em1/Cya
Common Name:
Orm1-KO
Product ID:
S-KO-18982
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Orm1-KO
Strain ID
KOCMP-18405-Orm1-B6J-VB
Gene Name
Product ID
S-KO-18982
Gene Alias
Agp-1; Agp-2; Orm-1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
4
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Orm1em1/Cya mice (Catalog S-KO-18982) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000030044
NCBI RefSeq
NM_008768
Target Region
Exon 1~3
Size of Effective Region
~2.3 kb
Detailed Document
Overview of Gene Research
ORM1, also known as orosomucoid 1 or alpha-1 acid glycoprotein (AGP), is an acute-phase protein mainly synthesized in the liver. It constitutes a major part of serum ORM. As a plasma drug-binding protein, it can bind and carry numerous basic and neutral lipophilic drugs, and its genetic polymorphism may influence the binding ability and effect of drugs [3,4].
In the context of tuberculosis, in Mycobacterium tuberculosis (Mtb) antigen-stimulated peripheral blood mononuclear cells (PBMCs), ORM1 shows a high area under the curve (AUC) value in discriminating patients with active TB from those with latent TB infection, suggesting it could be a potential biomarker for this discrimination [1]. Regarding venous thromboembolism (VTE), a multiallelic copy number variation (mCNV) in ORM1 is associated with plasma cell-free DNA (cfDNA) levels, which could contribute to VTE risk. Increased mCNV dosages in ORM1 decrease gene expression and upregulate cfDNA levels [2,5].
In conclusion, ORM1 is a significant protein involved in drug-binding and potentially in disease diagnosis. Its role as a biomarker in tuberculosis and its association with VTE risk through cfDNA levels regulation are important findings. These insights from studies contribute to understanding its functions in disease-related biological processes, providing potential directions for diagnosis and treatment in these disease areas.
References:
1. Yang, Bing-Fen, Zhai, Fei, Yu, Shan, Wang, Ruo, Cheng, Xiao-Xing. 2022. Evaluation of IFIT3 and ORM1 as Biomarkers for Discriminating Active Tuberculosis from Latent Infection. In Current medical science, 42, 1201-1212. doi:10.1007/s11596-022-2649-6. https://pubmed.ncbi.nlm.nih.gov/36462134/
2. Martin-Fernandez, Laura, Garcia-Martínez, Iris, Lopez, Sonia, Vidal, Francisco, Soria, Jose Manuel. 2023. Multiallelic Copy Number Variation in ORM1 is Associated with Plasma Cell-Free DNA Levels as an Intermediate Phenotype for Venous Thromboembolism. In Thrombosis and haemostasis, 123, 438-452. doi:10.1055/s-0043-1760844. https://pubmed.ncbi.nlm.nih.gov/36696913/
3. Wang, Lian Sheng, Shang, Jing Jing, Shi, Shu Ya, Jiang, Hai He, Xie, Hai Tang. 2012. Influence of ORM1 polymorphisms on the maintenance stable warfarin dosage. In European journal of clinical pharmacology, 69, 1113-20. doi:10.1007/s00228-012-1448-6. https://pubmed.ncbi.nlm.nih.gov/23208322/
4. Li, Jin Heng, Xu, Jing Qiu, Cao, Xiao Mei, Zhuang, Yi Yi, Gong, Jian Bin. . Influence of the ORM1 phenotypes on serum unbound concentration and protein binding of quinidine. In Clinica chimica acta; international journal of clinical chemistry, 317, 85-92. doi:. https://pubmed.ncbi.nlm.nih.gov/11814462/
5. Lopez, Sonia, Martinez-Perez, Angel, Rodriguez-Rius, Alba, Dermitzakis, Emmanouil T, Soria, Jose Manuel. 2022. Integrated GWAS and Gene Expression Suggest ORM1 as a Potential Regulator of Plasma Levels of Cell-Free DNA and Thrombosis Risk. In Thrombosis and haemostasis, 122, 1027-1039. doi:10.1055/s-0041-1742169. https://pubmed.ncbi.nlm.nih.gov/35272364/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen