C57BL/6JCya-Popdc3em1/Cya
Common Name:
Popdc3-KO
Product ID:
S-KO-19024
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Popdc3-KO
Strain ID
KOCMP-78977-Popdc3-B6J-VB
Gene Name
Product ID
S-KO-19024
Gene Alias
Pop3
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
10
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Popdc3em1/Cya mice (Catalog S-KO-19024) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000019994
NCBI RefSeq
NM_024286
Target Region
Exon 2
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
Popdc3, encoding a membrane protein, is a transmembrane protein with a unique cyclic adenosine monophosphate (cAMP) binding site. It is widely expressed in mammalian tissues, with high levels in skeletal muscle. POPDC3 is involved in cAMP signaling and plays a key role in many physiological and pathological processes. Its study using genetic models like gene knockout can help reveal its functions [1,2].
Research has identified homozygous POPDC3 missense variants in patients with a new form of limb-girdle muscular dystrophy (LGMD). Knockdown of popdc3 in zebrafish led to larvae with tail curling and dystrophic muscle features, indicating its importance for skeletal muscle function [2]. In addition, POPDC3 may serve as a potential biomarker. High POPDC3 expression correlated with poor prognosis in head and neck squamous cell carcinoma patients, while reduced Popdc3 expression was associated with high risk and poor survival in gastric cancer patients [3,4].
In conclusion, Popdc3 is crucial for skeletal muscle function and is associated with LGMD. Its abnormal expression is related to the prognosis of certain cancers. Studies using model organisms like zebrafish have been valuable in understanding its role in biological processes and disease conditions.
References：
1. Sun, Chen-Chen, Zhao, Zhe, Peng, Xi-Yang, Zheng, Lan, Tang, Chang-Fa. 2023. Progress on the study of Popeye domain-containing 3 (POPDC3) in malignancies and striated muscle function and homeostasis. In Clinical genetics, 103, 617-624. doi:10.1111/cge.14318. https://pubmed.ncbi.nlm.nih.gov/36843357/
2. Vissing, John, Johnson, Katherine, Töpf, Ana, Brand, Thomas, Straub, Volker. 2019. POPDC3 Gene Variants Associate with a New Form of Limb Girdle Muscular Dystrophy. In Annals of neurology, 86, 832-843. doi:10.1002/ana.25620. https://pubmed.ncbi.nlm.nih.gov/31610034/
3. He, Xu, Xu, Hongfa, Zhao, Wei, Tan, Li, Lu, Ligong. 2019. POPDC3 is a potential biomarker for prognosis and radioresistance in patients with head and neck squamous cell carcinoma. In Oncology letters, 18, 5468-5480. doi:10.3892/ol.2019.10888. https://pubmed.ncbi.nlm.nih.gov/31612055/
4. Luo, Deng, Lu, Ming-Liang, Zhao, Gong-Fang, Lv, Lin, Luo, Jin-Bo. . Reduced Popdc3 expression correlates with high risk and poor survival in patients with gastric cancer. In World journal of gastroenterology, 18, 2423-9. doi:10.3748/wjg.v18.i19.2423. https://pubmed.ncbi.nlm.nih.gov/22654436/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen