C57BL/6JCya-Mir690em1/Cya
Common Name
Mir690-KO
Product ID
S-KO-19046
Backgroud
C57BL/6JCya
Strain ID
KOCMP-751543-Mir690-B6J-VA
When using this mouse strain in a publication, please cite “Mir690-KO Mouse (Catalog S-KO-19046) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Mir690-KO
Strain ID
KOCMP-751543-Mir690-B6J-VA
Gene Name
Product ID
S-KO-19046
Gene Alias
Mirn690, mir-690, mmu-mir-690
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 16
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000102110
NCBI RefSeq
NR_030463
Target Region
Exon 1
Size of Effective Region
~0.1 kb
Overview of Gene Research
MiR-690 is a microRNA that has been implicated in multiple biological processes. It is involved in regulating insulin sensitivity, with a potential role in metabolic disease [1,2,3]. It also appears to play a part in the etiology of non-alcoholic steatohepatitis (NASH) [2].
In functional studies, miR-690 in M2-polarized macrophages is highly expressed in exosomes and improves insulin sensitivity in obese mice by targeting Nadk, which modulates macrophage inflammation and insulin signaling [1]. In NASH, Kupffer cells produce miR-690 and its deficiency promotes NASH pathogenesis. Administration of an miR-690 mimic robustly inhibits NASH features [2].
In conclusion, miR-690 is crucial in maintaining normal metabolic homeostasis, especially in relation to insulin sensitivity and NASH. The gene knockout (KO) or conditional knockout (CKO) mouse models used in these studies have been instrumental in revealing its role in these disease-related biological processes, offering potential therapeutic avenues for metabolic diseases like NASH and those associated with insulin resistance.
References：
1. Ying, Wei, Gao, Hong, Dos Reis, Felipe Castellani Gomes, Ly, Crystal, Olefsky, Jerrold M. 2021. MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice. In Cell metabolism, 33, 781-790.e5. doi:10.1016/j.cmet.2020.12.019. https://pubmed.ncbi.nlm.nih.gov/33450179/
2. Gao, Hong, Jin, Zhongmou, Bandyopadhyay, Gautam, Ying, Wei, Olefsky, Jerrold M. 2022. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. In Cell metabolism, 34, 978-990.e4. doi:10.1016/j.cmet.2022.05.008. https://pubmed.ncbi.nlm.nih.gov/35700738/
3. Rohm, Theresa V, Castellani Gomes Dos Reis, Felipe, Isaac, Roi, Wang, Allen, Olefsky, Jerrold M. 2024. Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization. In Nature metabolism, 6, 880-898. doi:10.1038/s42255-024-01023-w. https://pubmed.ncbi.nlm.nih.gov/38605183/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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