C57BL/6JCya-Hnrnpul1em1/Cya
Common Name
Hnrnpul1-KO
Product ID
S-KO-19103
Backgroud
C57BL/6JCya
Strain ID
KOCMP-232989-Hnrnpul1-B6J-VB
Status
When using this mouse strain in a publication, please cite “Hnrnpul1-KO Mouse (Catalog S-KO-19103) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Hnrnpul1-KO
Strain ID
KOCMP-232989-Hnrnpul1-B6J-VB
Gene Name
Product ID
S-KO-19103
Gene Alias
E1BAP5, E1B-AP5, Hnrnpul, Hnrpul1, E130317O14Rik
Background
C57BL/6JCya
Gene Full Name
heterogeneous nuclear ribonucleoprotein U-like 1
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 7 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000206832
NCBI Transcript ID
NM_144922
Target Region
Exon 4
Size of Effective Region
~1.4 kb
Overview of Gene Research
Hnrnpul1, known as heterogeneous nuclear ribonucleoprotein U-like 1, belongs to the family of RNA-binding proteins. It is involved in nucleic acid binding, transcription, and splicing, either by directly binding to DNA and RNA or through interacting with other proteins in the spliceosome. It plays a role in multiple biological processes and is potentially associated with various diseases [1,2,3,4,5].
In zebrafish, Hnrnpul1 mutants show reduced body and fin growth, missing bones, craniofacial tendon growth defects, and adult-onset caudal scoliosis. RNA-sequencing reveals its role in alternative splicing and transcriptional regulation, especially of genes related to translation, ubiquitination, and DNA damage [1]. In esophageal squamous cell carcinoma, reduced Hnrnpul1 expression enhances cisplatin sensitivity, and it inhibits cisplatin sensitivity by regulating the formation of circMAN1A2 [2]. In cervical cancer, NAT10-mediated RNA acetylation enhances Hnrnpul1 mRNA stability, promoting cancer progression [3]. In ovarian cancer, AKAP8 regulates the transcription of a specific Hnrnpul1 isoform, and AKAP8 inhibition can enhance PAPR inhibitor cytotoxicity [4]. In bladder cancer, LINC00461 promotes epithelial-mesenchymal transition (EMT) through the miR-518b/Hnrnpul1 axis [5].
In conclusion, Hnrnpul1 is crucial for normal development, as shown by zebrafish models, and is involved in the progression of multiple cancers. Studies on Hnrnpul1 in disease models help to understand its function in specific biological processes and offer potential therapeutic targets for related diseases such as esophageal, cervical, ovarian, and bladder cancers.
References：
1. Blackwell, Danielle L, Fraser, Sherri D, Caluseriu, Oana, Bernier, François P, Childs, Sarah J. . Hnrnpul1 controls transcription, splicing, and modulates skeletal and limb development in vivo. In G3 (Bethesda, Md.), 12, . doi:10.1093/g3journal/jkac067. https://pubmed.ncbi.nlm.nih.gov/35325113/
2. Li, Juan, Sang, Meixiang, Zheng, Yang, Li, Weijing, Shan, Baoen. 2021. HNRNPUL1 inhibits cisplatin sensitivity of esophageal squamous cell carcinoma through regulating the formation of circMAN1A2. In Experimental cell research, 409, 112891. doi:10.1016/j.yexcr.2021.112891. https://pubmed.ncbi.nlm.nih.gov/34688610/
3. Long, Yingfei, Ren, Yifei, Wei, Qinglv, Cheng, Lei, Yi, Ping. 2023. NAT10-mediated RNA acetylation enhances HNRNPUL1 mRNA stability to contribute cervical cancer progression. In International journal of medical sciences, 20, 1079-1090. doi:10.7150/ijms.83828. https://pubmed.ncbi.nlm.nih.gov/37484809/
4. Mobet, Youchaou, Wang, Haocheng, Wei, Qinglv, Liu, Tao, Yi, Ping. 2024. AKAP8 promotes ovarian cancer progression and antagonizes PARP inhibitor sensitivity through regulating hnRNPUL1 transcription. In iScience, 27, 109744. doi:10.1016/j.isci.2024.109744. https://pubmed.ncbi.nlm.nih.gov/38711442/
5. Zhou, Yijie, Zhao, Keyuan, Li, Junlong, Xu, Gang, Pan, Shouhua. 2024. LINC00461 promotes bladder cancer cells EMT through miR-518b/HNRNPUL1 axis. In Discover oncology, 15, 419. doi:10.1007/s12672-024-01294-5. https://pubmed.ncbi.nlm.nih.gov/39254804/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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