Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Hnrnpul1em1/Cya
Common Name:
Hnrnpul1-KO
Product ID:
S-KO-19103
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Hnrnpul1-KO
Strain ID
KOCMP-232989-Hnrnpul1-B6J-VB
Gene Name
Hnrnpul1
Product ID
S-KO-19103
Gene Alias
E130317O14Rik; E1B-AP5; E1BAP5; Hnrnpul; Hnrpul1
Background
C57BL/6JCya
NCBI ID
232989
Modification
Conventional knockout
Chromosome
7
Phenotype
MGI:2443517
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Hnrnpul1em1/Cya mice (Catalog S-KO-19103) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000206832
NCBI RefSeq
NM_144922
Target Region
Exon 4
Size of Effective Region
~1.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Hnrnpul1, known as heterogeneous nuclear ribonucleoprotein U-like 1, belongs to the family of RNA-binding proteins. It is involved in nucleic acid binding, transcription, and splicing, either by directly binding to DNA and RNA or through interacting with other proteins in the spliceosome. It plays a role in multiple biological processes and is potentially associated with various diseases [1,2,3,4,5].

In zebrafish, Hnrnpul1 mutants show reduced body and fin growth, missing bones, craniofacial tendon growth defects, and adult-onset caudal scoliosis. RNA-sequencing reveals its role in alternative splicing and transcriptional regulation, especially of genes related to translation, ubiquitination, and DNA damage [1]. In esophageal squamous cell carcinoma, reduced Hnrnpul1 expression enhances cisplatin sensitivity, and it inhibits cisplatin sensitivity by regulating the formation of circMAN1A2 [2]. In cervical cancer, NAT10-mediated RNA acetylation enhances Hnrnpul1 mRNA stability, promoting cancer progression [3]. In ovarian cancer, AKAP8 regulates the transcription of a specific Hnrnpul1 isoform, and AKAP8 inhibition can enhance PAPR inhibitor cytotoxicity [4]. In bladder cancer, LINC00461 promotes epithelial-mesenchymal transition (EMT) through the miR-518b/Hnrnpul1 axis [5].

In conclusion, Hnrnpul1 is crucial for normal development, as shown by zebrafish models, and is involved in the progression of multiple cancers. Studies on Hnrnpul1 in disease models help to understand its function in specific biological processes and offer potential therapeutic targets for related diseases such as esophageal, cervical, ovarian, and bladder cancers.

References:
1. Blackwell, Danielle L, Fraser, Sherri D, Caluseriu, Oana, Bernier, François P, Childs, Sarah J. . Hnrnpul1 controls transcription, splicing, and modulates skeletal and limb development in vivo. In G3 (Bethesda, Md.), 12, . doi:10.1093/g3journal/jkac067. https://pubmed.ncbi.nlm.nih.gov/35325113/
2. Li, Juan, Sang, Meixiang, Zheng, Yang, Li, Weijing, Shan, Baoen. 2021. HNRNPUL1 inhibits cisplatin sensitivity of esophageal squamous cell carcinoma through regulating the formation of circMAN1A2. In Experimental cell research, 409, 112891. doi:10.1016/j.yexcr.2021.112891. https://pubmed.ncbi.nlm.nih.gov/34688610/
3. Long, Yingfei, Ren, Yifei, Wei, Qinglv, Cheng, Lei, Yi, Ping. 2023. NAT10-mediated RNA acetylation enhances HNRNPUL1 mRNA stability to contribute cervical cancer progression. In International journal of medical sciences, 20, 1079-1090. doi:10.7150/ijms.83828. https://pubmed.ncbi.nlm.nih.gov/37484809/
4. Mobet, Youchaou, Wang, Haocheng, Wei, Qinglv, Liu, Tao, Yi, Ping. 2024. AKAP8 promotes ovarian cancer progression and antagonizes PARP inhibitor sensitivity through regulating hnRNPUL1 transcription. In iScience, 27, 109744. doi:10.1016/j.isci.2024.109744. https://pubmed.ncbi.nlm.nih.gov/38711442/
5. Zhou, Yijie, Zhao, Keyuan, Li, Junlong, Xu, Gang, Pan, Shouhua. 2024. LINC00461 promotes bladder cancer cells EMT through miR-518b/HNRNPUL1 axis. In Discover oncology, 15, 419. doi:10.1007/s12672-024-01294-5. https://pubmed.ncbi.nlm.nih.gov/39254804/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest