C57BL/6JCya-Grhprem1/Cya
Common Name
Grhpr-KO
Product ID
S-KO-19104
Backgroud
C57BL/6JCya
Strain ID
KOCMP-76238-Grhpr-B6J-VB
Status
When using this mouse strain in a publication, please cite “Grhpr-KO Mouse (Catalog S-KO-19104) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Grhpr-KO
Strain ID
KOCMP-76238-Grhpr-B6J-VB
Gene Name
Product ID
S-KO-19104
Gene Alias
Glxr, 1110059D05Rik, 6430629L09Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000045078
NCBI RefSeq
NM_080289
Target Region
Exon 3~4
Size of Effective Region
~1.5 kb
Overview of Gene Research
GRHPR, known as Glyoxylate reductase/hydroxypyruvate reductase, is a D-2-hydroxy-acid dehydrogenase mainly existing in the liver. It plays a critical role in the formation of primary hyperoxaluria type 2 (PH2) [4].
In hepatocellular carcinoma (HCC), overexpression of GRHPR suppresses cell proliferation, migration, and invasion, acting as a tumor suppressor regulated by miR-138-5p through the PI3K/AKT signaling pathway [1].
In West Bengal, India, a homozygous GRHPR c.494G>A mutation was found to cause early onset of nephrolithiasis, with the mutation being pathogenic with loss of function [2].
In non-small cell lung cancer (NSCLC), the circular RNA circ_GRHPR promotes cell proliferation and invasion by interacting with the RNA-binding protein PCBP2 [3].
In TNBS-induced experimental colitis, up-regulation of GRHPR is associated with intestinal epithelial cells apoptosis, potentially serving as a therapeutic target for Crohn's disease [4].
In conclusion, GRHPR is involved in multiple biological processes and diseases. Its function in tumor suppression in HCC, role in causing nephrolithiasis, and impact on NSCLC cell behavior as well as in experimental colitis demonstrate its significance. Research on GRHPR helps understand disease mechanisms and could potentially lead to new therapeutic strategies for related diseases.
References：
1. Yang, Shuangshuang, Liu, Yixian, Zhang, Bushi, Zhao, Qianwei, Zhang, Jintao. 2024. GRHPR, Targeted by miR-138-5p, Inhibits the Proliferation and Metastasis of Hepatocellular Carcinoma Through PI3K/AKT Signaling Pathway. In Cancer biotherapy & radiopharmaceuticals, 39, 733-744. doi:10.1089/cbr.2023.0018. https://pubmed.ncbi.nlm.nih.gov/38934120/
2. Chatterjee, Arindam, Sarkar, Kunal, Bank, Sarbashri, Chattopadhyay, Debprasad, Das, Madhusudan. 2022. Homozygous GRHPR C.494G>A mutation is deleterious that causes early onset of nephrolithiasis in West Bengal, India. In Frontiers in molecular biosciences, 9, 1049620. doi:10.3389/fmolb.2022.1049620. https://pubmed.ncbi.nlm.nih.gov/36619171/
3. Hou, Yanyan, Lin, Jiafei, Wang, Danyang, Liu, Xiangfan, Ni, Peihua. 2021. The circular RNA circ_GRHPR promotes NSCLC cell proliferation and invasion via interactions with the RNA-binding protein PCBP2. In Clinical and experimental pharmacology & physiology, 48, 1171-1181. doi:10.1111/1440-1681.13523. https://pubmed.ncbi.nlm.nih.gov/33987874/
4. Zong, Chunyan, Nie, Xiaoke, Zhang, Dongmei, Liu, Yifei, Zhou, Guoxiong. 2015. Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis. In Pathology, research and practice, 212, 365-71. doi:10.1016/j.prp.2015.09.019. https://pubmed.ncbi.nlm.nih.gov/26997491/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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