C57BL/6JCya-Iqcf3em1/Cya
Common Name:
Iqcf3-KO
Product ID:
S-KO-19123
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Iqcf3-KO
Strain ID
KOCMP-68265-Iqcf3-B6J-VB
Gene Name
Product ID
S-KO-19123
Gene Alias
1700012F17Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Iqcf3em1/Cya mice (Catalog S-KO-19123) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000062917
NCBI RefSeq
NM_026645
Target Region
Exon 4~6
Size of Effective Region
~2.0 kb
Detailed Document
Overview of Gene Research
Check the content of the review
Iqcf3, the exact nature of its essential function, associated pathways, and overall biological importance remain largely unknown as no such information was provided in the reference. But gene-based studies can potentially shed light on these aspects.
A gene-based association analysis identified Iqcf3 (p = 2.0×10⁻⁶) as a significant gene associated with keratitis in a study of 337,199 subjects of European ancestry in the UK Biobank cohort [1]. The overlap of Iqcf3 in SNP-based and gene-based analyses resulted in a total of 33 hub genes. Functional annotation of these hub genes was performed and transcriptional factors of Iqcf3 were predicted [1].
In conclusion, Iqcf3 has been identified as a candidate gene underlying keratitis through gene-based association analysis. The study indicates its potential importance in the context of keratitis, although more research is needed to fully understand its biological functions and how it might contribute to the disease.
References：
1. Xu, Yue, Yang, Xiao-Lin, Yang, Xiao-Long, Zhang, Lei, Zhang, Xiao-Feng. 2020. Functional Annotations of Single-Nucleotide Polymorphism (SNP)-Based and Gene-Based Genome-Wide Association Studies Show Genes Affecting Keratitis Susceptibility. In Medical science monitor : international medical journal of experimental and clinical research, 26, e922710. doi:10.12659/MSM.922710. https://pubmed.ncbi.nlm.nih.gov/32450567/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen