C57BL/6JCya-Mrps15em1/Cya
Common Name
Mrps15-KO
Product ID
S-KO-19134
Backgroud
C57BL/6JCya
Strain ID
KOCMP-66407-Mrps15-B6J-VB
When using this mouse strain in a publication, please cite “Mrps15-KO Mouse (Catalog S-KO-19134) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Mrps15-KO
Strain ID
KOCMP-66407-Mrps15-B6J-VB
Gene Name
Product ID
S-KO-19134
Gene Alias
1500003E24Rik, 2410002B11Rik, Mprs15
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000030675
NCBI RefSeq
NM_025544
Target Region
Exon 3~4
Size of Effective Region
~2.8 kb
Overview of Gene Research
Mrps15, a mitochondrial ribosomal protein gene, is a crucial component for the structural and functional integrity of the mitoribosome complex [1]. Mitoribosomes are essential for mitochondrial translation, which is vital for the production of protein components of the oxidative phosphorylation (OXPHOS) complex, thus playing a significant role in cellular energy metabolism [5].
In stressed cardiomyocytes, MRPS15 translocates to cytosolic ribosomes and regulates internal ribosome entry site (IRES)-dependent translation, highlighting its role in controlling gene expression under stress [2]. In hepatocellular carcinoma (HCC), a prognostic model integrating MRPS15 and other genes attains a greater clinical net benefit, suggesting its potential in predicting prognosis [3]. In lung adenocarcinoma, MRPS15 is identified as a hub gene, and its overexpression is associated with poor overall survival [4]. In collagen VI-related dystrophies, MRPS15 is recognized as a potential hub gene involved in the disease [6].
In conclusion, Mrps15 is essential for mitoribosome function and mitochondrial translation. Its role in various disease conditions such as in cardiomyocyte stress response, HCC prognosis, lung adenocarcinoma progression, and collagen VI-related dystrophies has been revealed through different research models. These findings enhance our understanding of its biological functions and offer potential implications for disease diagnosis, prognosis, and treatment.
References：
1. Cheong, Agnes, Lingutla, Ranjana, Mager, Jesse. 2020. Expression analysis of mammalian mitochondrial ribosomal protein genes. In Gene expression patterns : GEP, 38, 119147. doi:10.1016/j.gep.2020.119147. https://pubmed.ncbi.nlm.nih.gov/32987154/
2. David, Florian, Roussel, Emilie, Froment, Carine, Garmy-Susini, Barbara, Prats, Anne-Catherine. 2024. Mitochondrial Ribosomal Protein MRPS15 Is a Component of Cytosolic Ribosomes and Regulates Translation in Stressed Cardiomyocytes. In International journal of molecular sciences, 25, . doi:10.3390/ijms25063250. https://pubmed.ncbi.nlm.nih.gov/38542224/
3. Zhao, Jin-Wei, Zhao, Wei-Yi, Cui, Xin-Hua, Shi, Jia-Cheng, Yu, Lu. 2023. The role of the mitochondrial ribosomal protein family in detecting hepatocellular carcinoma and predicting prognosis, immune features, and drug sensitivity. In Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 26, 496-514. doi:10.1007/s12094-023-03269-4. https://pubmed.ncbi.nlm.nih.gov/37407805/
4. Mukherjee, Arnab, Boonbangyang, Manon, K S, Mukunthan. 2025. Unraveling the intricate molecular landscape and potential biomarkers in lung adenocarcinoma through integrative epigenomic and transcriptomic profiling. In Scientific reports, 15, 9154. doi:10.1038/s41598-025-93769-w. https://pubmed.ncbi.nlm.nih.gov/40097569/
5. Sotgia, Federica, Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E, Howell, Anthony, Lisanti, Michael P. 2012. Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. In Cell cycle (Georgetown, Tex.), 11, 4390-401. doi:10.4161/cc.22777. https://pubmed.ncbi.nlm.nih.gov/23172368/
6. Ceyhan, Atakan Burak, Kaynar, Ali, Altay, Ozlem, Turkez, Hasan, Mardinoglu, Adil. 2024. Identifying Hub Genes and Metabolic Pathways in Collagen VI-Related Dystrophies: A Roadmap to Therapeutic Intervention. In Biomolecules, 14, . doi:10.3390/biom14111376. https://pubmed.ncbi.nlm.nih.gov/39595553/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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