C57BL/6JCya-Try10em1/Cya
Common Name
Try10-KO
Product ID
S-KO-19150
Backgroud
C57BL/6JCya
Strain ID
KOCMP-436522-Try10-B6J-VA
When using this mouse strain in a publication, please cite “Try10-KO Mouse (Catalog S-KO-19150) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Try10-KO
Strain ID
KOCMP-436522-Try10-B6J-VA
Gene Name
Product ID
S-KO-19150
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 6
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000072103
NCBI RefSeq
NM_001038996
Target Region
Exon 2~5
Size of Effective Region
~4.1 kb
Overview of Gene Research
Try10 is a gene that has been associated with certain biological processes in the context of retinal ganglion cell (RGC) degeneration and hepatic glucagon receptor-related functions. However, specific details about its function, associated pathways, and overall biological importance are not comprehensively described in the provided references.
In the study on RGC degeneration, Try10 was among eight proteins that were differentially expressed for at least two time points in the temporal retina compared to the nasal retina after unilateral partial optic nerve transection in rats. This indicates its potential involvement in the response to RGC damage [1].
In the research on the hepatic glucagon receptor, [125I-Try10]monoiodoglucagon was used to covalently label the receptor, suggesting Try10 might be relevant in the study of the hepatic glucagon receptor's properties, such as its solubilization, characterization, and the development of an affinity adsorption assay [2].
In conclusion, Try10 shows potential associations with RGC damage response and hepatic glucagon receptor-related functions. Although more research is needed to fully understand its essential biological functions, these initial findings from the respective research models provide a starting point for further exploration into its role in related disease areas like retinal neurodegeneration and hepatic receptor-mediated disorders.
References：
1. Kwong, Jacky M K, Caprioli, Joseph, Lee, Joanne C Y, To, Chi-Ho, Lam, Thomas Chuen. 2023. Differential Responses of Retinal Neurons and Glia Revealed via Proteomic Analysis on Primary and Secondary Retinal Ganglion Cell Degeneration. In International journal of molecular sciences, 24, . doi:10.3390/ijms241512109. https://pubmed.ncbi.nlm.nih.gov/37569482/
2. Herberg, J T, Codina, J, Rich, K A, Rojas, F J, Iyengar, R. . The hepatic glucagon receptor. Solubilization, characterization, and development of an affinity adsorption assay for the soluble receptor. In The Journal of biological chemistry, 259, 9285-94. doi:. https://pubmed.ncbi.nlm.nih.gov/6086631/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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