C57BL/6JCya-Serpina3mem1/Cya
Common Name:
Serpina3m-KO
Product ID:
S-KO-19157
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Serpina3m-KO
Strain ID
KOCMP-20717-Serpina3m-B6J-VA
Gene Name
Product ID
S-KO-19157
Gene Alias
3e46; MMCM7; MMSPi2.4; Spi-2l; Spi-2rs1; Spi2-rs1; Spi2.4; spi2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
12
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Serpina3mem1/Cya mice (Catalog S-KO-19157) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000168797
NCBI RefSeq
NM_009253
Target Region
Exon 2~5
Size of Effective Region
~5.4 kb
Detailed Document
Overview of Gene Research
Serpina3m, a gene with its function not comprehensively defined yet, seems to be involved in multiple biological processes. Its potential association with inflammation, apoptosis, and immune-related pathways is indicated by various studies [1,2]. Genetic models, especially mouse models, can be valuable in further exploring its functions.
In a study on kidney ischemia/reperfusion injury in mice, combined treatment of an erythropoietin-derived peptide and caspase-3 siRNA led to up-regulation of Serpina3m, which was associated with modulated apoptosis and inflammation, as well as immunity, injury, and microvascular homeostasis [2]. In an aging-and alcohol-associated acute pancreatitis mouse model, Serpina3m was among the top five differentially expressed genes (DEGs) upregulated in aging mice compared to young mice, suggesting its role in the heterogeneous inflammatory processes of aging-related AAP [1]. Additionally, in a study on Shen Lin Bai Zhu San n-butanol extract's effect on DSS-induced colitis in mice, Serpina3m was closely related to colitis and was restored by the extract, indicating its potential role in colitis-related biological functions [3].
In conclusion, Serpina3m appears to play important roles in inflammation, apoptosis, and immune-related processes as revealed through mouse-based research. Its involvement in diseases such as acute pancreatitis, kidney ischemia/reperfusion injury, and colitis provides insights into potential molecular mechanisms underlying these diseases, which may offer new directions for diagnosis and treatment.
References:
1. Tindall, Rachel R, Yang, Yuntao, Hernandez, Isabella, Zheng, W Jim, Ko, Tien C. 2024. Aging- and alcohol-associated spatial transcriptomic signature in mouse acute pancreatitis reveals heterogeneity of inflammation and potential pathogenic factors. In Journal of molecular medicine (Berlin, Germany), 102, 1051-1061. doi:10.1007/s00109-024-02460-6. https://pubmed.ncbi.nlm.nih.gov/38940937/
2. Wu, Yuanyuan, Chen, Weiwei, Zhang, Yufang, Fan, Yaping, Yang, Bin. 2020. Potent Therapy and Transcriptional Profile of Combined Erythropoietin-Derived Peptide Cyclic Helix B Surface Peptide and Caspase-3 siRNA against Kidney Ischemia/Reperfusion Injury in Mice. In The Journal of pharmacology and experimental therapeutics, 375, 92-103. doi:10.1124/jpet.120.000092. https://pubmed.ncbi.nlm.nih.gov/32759272/
3. Qu, Qian, Li, Shu-Peng, Dong, Qi, Lv, Wei-Jie, Guo, Shi-Ning. 2023. Transcriptome profiling Revealed the potential mechanisms of Shen Lin Bai Zhu San n-butanol extract on DSS induced Colitis in Mice and LC-MS analysis. In Phytomedicine : international journal of phytotherapy and phytopharmacology, 110, 154645. doi:10.1016/j.phymed.2023.154645. https://pubmed.ncbi.nlm.nih.gov/36634382/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen