C57BL/6JCya-Ankrd60em1/Cya
Common Name:
Ankrd60-KO
Product ID:
S-KO-19164
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ankrd60-KO
Strain ID
KOCMP-70065-Ankrd60-B6J-VB
Gene Name
Product ID
S-KO-19164
Gene Alias
1700019A24Rik; 1700030G11Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ankrd60em1/Cya mice (Catalog S-KO-19164) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000239457
NCBI RefSeq
NM_027303
Target Region
Exon 2
Size of Effective Region
~0.1 kb
Detailed Document
Overview of Gene Research
Ankrd60, also known as ankyrin repeat domain 60, has been associated with multiple biological aspects. In humans, it is associated with body height, as identified in a Korean population study where it was among 15 loci influencing height [3]. It is also potentially linked to adolescent idiopathic scoliosis [2].
In Nordic Red cattle, Ankrd60 was identified as a candidate gene for the female fertility index (FTI), which includes sub-traits like number of inseminations per conception and intervals between inseminations. Although the exact mechanism of how Ankrd60 regulates female fertility is unknown, the gene was located on a chromosome associated with FTI [1]. In Icelandic horses, Ankrd60 is in a genomic region associated with the conformation of back and croup, which influences the quality of lateral gaits [2].
In conclusion, Ankrd60 appears to play important roles in diverse biological processes across different species, including height regulation in humans, female fertility in cattle, and back and croup conformation affecting gait in horses. These findings from different research models provide insights into the gene's functions and potential implications in various biological and breeding-related contexts. [1,2,3]
References:
1. Höglund, Johanna K, Buitenhuis, Bart, Guldbrandtsen, Bernt, Lund, Mogens S, Sahana, Goutam. 2015. Genome-wide association study for female fertility in Nordic Red cattle. In BMC genetics, 16, 110. doi:10.1186/s12863-015-0269-x. https://pubmed.ncbi.nlm.nih.gov/26369327/
2. Rosengren, Maria K, Sigurðardóttir, Heiðrún, Eriksson, Susanne, Solé, Marina, Lindgren, Gabriella. 2021. A QTL for conformation of back and croup influences lateral gait quality in Icelandic horses. In BMC genomics, 22, 267. doi:10.1186/s12864-021-07454-z. https://pubmed.ncbi.nlm.nih.gov/33853519/
3. Kim, Jae-Jung, Lee, Hae-In, Park, Taesung, Yoo, Han-Wook, Lee, Jong-Keuk. 2009. Identification of 15 loci influencing height in a Korean population. In Journal of human genetics, 55, 27-31. doi:10.1038/jhg.2009.116. https://pubmed.ncbi.nlm.nih.gov/19893584/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen