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C57BL/6JCya-Focadem1/Cya
Common Name:
Focad-KO
Product ID:
S-KO-19167
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Focad-KO
Strain ID
KOCMP-230393-Focad-B6J-VB
Gene Name
Focad
Product ID
S-KO-19167
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
230393
Modification
Conventional knockout
Chromosome
4
Phenotype
MGI:2676921
Document
Click here to download >>
Application
--
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Focadem1/Cya mice (Catalog S-KO-19167) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000097992
NCBI RefSeq
NM_001081184
Target Region
Exon 4
Size of Effective Region
~1.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
FOCAD, also known as KIAA1797, encodes a novel focal adhesion protein. It functions as a tumor suppressor in various cancers and is involved in pathways like the SKI mRNA surveillance pathway. FOCAD is crucial for maintaining liver homeostasis and impacts processes such as microtubule assembly and cell cycle progression [2,3,4]. Genetic models, including zebrafish lacking focad and gene knockout in human hepatic cell lines, have been used to study its functions [1].

In the context of diseases, loss of FOCAD in zebrafish phenocopied pediatric liver cirrhosis in humans, revealing its importance in the SKI mRNA surveillance pathway. Deficiency in FOCAD compromises this pathway by reducing levels of RNA helicase SKIC2 and its cofactor SKIC3. FOCAD knockout hepatocytes showed lowered albumin expression, signs of persistent injury, and CCL2 overproduction [1]. In astrocytic gliomas, FOCAD loss was associated with inferior patient outcomes, as it enhanced microtubule assembly and accelerated G2/M phase progression [3]. In gastric cancer, FOCAD was found to be a tumor suppressor, with its down-regulation promoting cell proliferation and migration [2].

In conclusion, FOCAD has essential functions in maintaining liver homeostasis and acts as a tumor suppressor in multiple cancers. Gene knockout and other genetic models have been instrumental in revealing its role in specific biological processes and disease conditions, such as pediatric liver cirrhosis and gliomas, providing potential therapeutic intervention points.

References:
1. Moreno Traspas, Ricardo, Teoh, Tze Shin, Wong, Pui-Mun, Girisha, Katta Mohan, Reversade, Bruno. 2022. Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis. In Nature genetics, 54, 1214-1226. doi:10.1038/s41588-022-01120-0. https://pubmed.ncbi.nlm.nih.gov/35864190/
2. Sun, Ruifang, Liu, Zhigang, Lv, Yun, Ding, Caixia, Zhou, Dangxia. 2022. FOCAD/miR-491-5p, downregulated by EGR1, function as tumor suppressor by inhibiting the proliferation and migration of gastric cancer cells. In Progress in biophysics and molecular biology, 176, 25-37. doi:10.1016/j.pbiomolbio.2022.06.003. https://pubmed.ncbi.nlm.nih.gov/35788362/
3. Brand, Frank, Förster, Alisa, Christians, Anne, Weller, Michael, Weber, Ruthild G. 2019. FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas. In Acta neuropathologica, 139, 175-192. doi:10.1007/s00401-019-02067-z. https://pubmed.ncbi.nlm.nih.gov/31473790/
4. Brockschmidt, Antje, Trost, Detlef, Peterziel, Heike, Angel, Peter, Weber, Ruthild G. 2012. KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas. In Brain : a journal of neurology, 135, 1027-41. doi:10.1093/brain/aws045. https://pubmed.ncbi.nlm.nih.gov/22427331/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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