C57BL/6JCya-Psmg1em1/Cya
Common Name:
Psmg1-KO
Product ID:
S-KO-19185
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Psmg1-KO
Strain ID
KOCMP-56088-Psmg1-B6J-VA
Gene Name
Product ID
S-KO-19185
Gene Alias
Dscr2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
16
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Psmg1em1/Cya mice (Catalog S-KO-19185) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000023630
NCBI RefSeq
NM_019537
Target Region
Exon 2~4
Size of Effective Region
~3.3 kb
Detailed Document
Overview of Gene Research
Psmg1, known as proteasome assembly chaperone 1, plays a role in processes related to protein degradation. It is associated with pathways such as autophagy, which is crucial for maintaining cellular homeostasis by degrading damaged proteins and organelles. Psmg1's importance lies in its potential influence on various biological processes and disease-related pathways [6].
In the context of diseases, Psmg1 has been implicated in multiple conditions. In childhood-onset inflammatory bowel disease (IBD), its role is discussed in relation to abnormal protein degradation and the secondary immune response, suggesting its involvement in the pathophysiology of intestinal inflammation [1]. In colon cancer, a ten-gene risk score prognostic model including Psmg1 was established, which can effectively predict patient survival rates, indicating its potential as a prognostic marker [2]. In prostate cancer, miR-484 was found to directly target Psmg1, and the miR-484-Psmg1 axis is hypothesized to be involved in increasing cancer cell mobility [3]. In Takayasu arteritis, a locus near Psmg1 has been identified as a non-HLA susceptibility locus [4]. In adult acute myeloid leukemia (AML), a model including Psmg1 was developed to predict overall survival (OS), with high-risk score patients showing poorer outcomes, highlighting its significance in risk classification for AML [5]. In an Italian cohort of IBD patients, the PSMG1 gene was associated with ulcerative colitis (UC), and the association was also confirmed in the pediatric cohort [7]. In autoimmune liver diseases, PSMG1 was found to be shared with some extrahepatic autoimmune diseases (EHAIDs) in primary sclerosing cholangitis (PSC), contributing to the understanding of the genetic basis and associations [8]. In long-lived rodents, PSMG1 showed signatures of positive selection in genes associated with lifespan, indicating its potential role in lifespan determination [9].
In conclusion, Psmg1 is a significant gene involved in protein-related processes and is associated with multiple diseases including IBD, colon cancer, prostate cancer, Takayasu arteritis, AML, and autoimmune liver diseases. The studies on Psmg1 contribute to understanding disease mechanisms and potential prognostic markers or therapeutic targets. Although no gene knockout (KO) or conditional knockout (CKO) mouse model findings were in the provided abstracts, the existing research on Psmg1 in various disease models shows its importance in disease-related biological processes.
References:
1. Henderson, Paul, van Limbergen, Johan E, Wilson, David C, Satsangi, Jack, Russell, Richard K. . Genetics of childhood-onset inflammatory bowel disease. In Inflammatory bowel diseases, 17, 346-61. doi:10.1002/ibd.21283. https://pubmed.ncbi.nlm.nih.gov/20839313/
2. Tang, Yini, Sang, Shuliu, Gao, Shuang, Zhou, Hailun, Xia, Xiaoting. 2024. Mechanistic insights into super-enhancer-related genes as prognostic signatures in colon cancer. In Aging, 16, 9918-9932. doi:10.18632/aging.205906. https://pubmed.ncbi.nlm.nih.gov/38850524/
3. Lee, Daniel, Tang, Wei, Dorsey, Tiffany H, Ambs, Stefan. . miR-484 is associated with disease recurrence and promotes migration in prostate cancer. In Bioscience reports, 40, . doi:10.1042/BSR20191028. https://pubmed.ncbi.nlm.nih.gov/32338277/
4. Renauer, Paul, Sawalha, Amr H. 2017. The genetics of Takayasu arteritis. In Presse medicale (Paris, France : 1983), 46, e179-e187. doi:10.1016/j.lpm.2016.11.031. https://pubmed.ncbi.nlm.nih.gov/28756073/
5. Sheng, Guangying, Tao, Jingfen, Jin, Peng, Jin, Wen, Wang, Kankan. 2024. The Proteasome-Family-Members-Based Prognostic Model Improves the Risk Classification for Adult Acute Myeloid Leukemia. In Biomedicines, 12, . doi:10.3390/biomedicines12092147. https://pubmed.ncbi.nlm.nih.gov/39335660/
6. Corona Velazquez, Angel, Corona, Abigail K, Klein, Kathryn A, Jackson, William T. 2018. Poliovirus induces autophagic signaling independent of the ULK1 complex. In Autophagy, 14, 1201-1213. doi:10.1080/15548627.2018.1458805. https://pubmed.ncbi.nlm.nih.gov/29929428/
7. Latiano, Anna, Palmieri, Orazio, Latiano, Tiziana, Andriulli, Angelo, Annese, Vito. 2011. Investigation of multiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients. In PloS one, 6, e22688. doi:10.1371/journal.pone.0022688. https://pubmed.ncbi.nlm.nih.gov/21818367/
8. Zhang, Zheng, Zhang, Jiayi, Yan, Xinyang, Liu, Qingguang, Han, Shaoshan. 2024. Dissecting the genetic basis and mechanisms underlying the associations between multiple extrahepatic factors and autoimmune liver diseases. In Journal of translational autoimmunity, 10, 100260. doi:10.1016/j.jtauto.2024.100260. https://pubmed.ncbi.nlm.nih.gov/39741931/
9. Sahm, Arne, Bens, Martin, Szafranski, Karol, Dammann, Philip, Platzer, Matthias. 2018. Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. In PLoS genetics, 14, e1007272. doi:10.1371/journal.pgen.1007272. https://pubmed.ncbi.nlm.nih.gov/29570707/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen