Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Lama1em1/Cya
Common Name:
Lama1-KO
Product ID:
S-KO-19188
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Lama1-KO
Strain ID
KOCMP-16772-Lama1-B6J-VA
Gene Name
Lama1
Product ID
S-KO-19188
Gene Alias
Lama
Background
C57BL/6JCya
NCBI ID
16772
Modification
Conventional knockout
Chromosome
17
Phenotype
MGI:99892
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lama1em1/Cya mice (Catalog S-KO-19188) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000035471
NCBI RefSeq
NM_008480
Target Region
Exon 2~3
Size of Effective Region
~1.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
LAMA1, also known as laminin subunit α1, is a member of the laminin family and a key basement membrane molecule [5]. Laminins are crucial for various biological activities, including cell adhesion, migration, and differentiation, and are involved in many biological processes and disease-related pathways [5]. Genetic models, such as mouse models, are valuable for studying LAMA1.

In Lama2-related congenital muscular dystrophy (LAMA2-CMD), Lama1 upregulation has shown therapeutic potential. In the dyH/dyH mouse model (a Lama2 exon-3-deletion mouse model), CRISPRa-mediated Lama1 upregulation nearly doubled the median survival, improved weight and grip, and had positive effects on MRI, serum biochemical indices, and muscle pathology [2]. In Merosin-deficient congenital muscular dystrophy (MDC1A) fibroblasts with LAMA2 mutations, CRISPRa-mediated LAMA1 upregulation compensated for LAMA2 deficiency, rescued cellular abnormalities, and decreased the expression of genes involved in the wound-healing mechanism [1].

In Lama1nmf223 mutant mice, abnormal axonal transport and optic nerve structure were observed in response to experimental glaucoma, suggesting a role of LAMA1 in the eye [3]. Also, Lama1 mutations in mice led to abnormal retinal vascular development, persistence of fetal vasculature, and epiretinal membrane formation, indicating its importance in retinal development [6,8]. In humans, biallelic mutations in LAMA1 cause Poretti-Boltshauser Syndrome (PTBHS), a non-progressive cerebellar dysplasia disorder with ophthalmic manifestations [4,7].

In conclusion, LAMA1 is essential for normal development, especially in muscle and eye tissues. Mouse models, including gene-modified ones, have revealed its role in diseases like LAMA2-CMD, MDC1A, and certain eye disorders. Understanding LAMA1 through these models provides insights into the underlying mechanisms of these diseases and potential therapeutic strategies.

References:
1. Arockiaraj, Annie I, Johnson, Marie A, Munir, Anushe, McAllister-Lucas, Linda M, Kemaladewi, Dwi U. 2023. CRISPRa-induced upregulation of human LAMA1 compensates for LAMA2-deficiency in Merosin-deficient congenital muscular dystrophy. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.03.06.531347. https://pubmed.ncbi.nlm.nih.gov/36945402/
2. Liu, Yidan, Tan, Dandan, Ma, Kaiyue, Zhang, Hong, Xiong, Hui. 2024. Lama1 upregulation prolongs the lifespan of the dyH/dyH mouse model of LAMA2-related congenital muscular dystrophy. In Journal of genetics and genomics = Yi chuan xue bao, 51, 1066-1078. doi:10.1016/j.jgg.2024.05.005. https://pubmed.ncbi.nlm.nih.gov/38777118/
3. Madhoun, Salaheddine, Martins, Manuela Tosi Comelis, Korneva, Arina, Edwards, Malia, Quigley, Harry. 2022. Effects of experimental glaucoma in Lama1nmf223 mutant mice. In Experimental eye research, 226, 109341. doi:10.1016/j.exer.2022.109341. https://pubmed.ncbi.nlm.nih.gov/36476399/
4. Schiff, Elena R, Aychoua, Nancy, Nutan, Savita, Webster, Andrew R, Arno, Gavin. 2022. Variability of retinopathy consequent upon novel mutations in LAMA1. In Ophthalmic genetics, 43, 671-678. doi:10.1080/13816810.2022.2076283. https://pubmed.ncbi.nlm.nih.gov/35616092/
5. Zhang, Shaoyuan, Fang, Yong, Su, Feng, Tan, Lijie, Yin, Jun. 2023. Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population. In Journal of oncology, 2023, 6922909. doi:10.1155/2023/6922909. https://pubmed.ncbi.nlm.nih.gov/36824663/
6. Edwards, Malia M, McLeod, D Scott, Grebe, Rhonda, Lefebvre, Olivier, Lutty, Gerard A. 2011. Lama1 mutations lead to vitreoretinal blood vessel formation, persistence of fetal vasculature, and epiretinal membrane formation in mice. In BMC developmental biology, 11, 60. doi:10.1186/1471-213X-11-60. https://pubmed.ncbi.nlm.nih.gov/21999428/
7. Powell, Laura, Olinger, Eric, Wedderburn, Sarah, Boltshauser, Eugen, Sayer, John A. 2021. Identification of LAMA1 mutations ends diagnostic odyssey and has prognostic implications for patients with presumed Joubert syndrome. In Brain communications, 3, fcab163. doi:10.1093/braincomms/fcab163. https://pubmed.ncbi.nlm.nih.gov/34423300/
8. Edwards, Malia M, Mammadova-Bach, Elmina, Alpy, Fabien, Lefebvre, Olivier, Nishina, Patsy M. 2010. Mutations in Lama1 disrupt retinal vascular development and inner limiting membrane formation. In The Journal of biological chemistry, 285, 7697-711. doi:10.1074/jbc.M109.069575. https://pubmed.ncbi.nlm.nih.gov/20048158/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest