C57BL/6JCya-Snord59aem1/Cya
Common Name:
Snord59a-KO
Product ID:
S-KO-19202
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Snord59a-KO
Strain ID
KOCMP-115487514-Snord59a-B6J-VA
Gene Name
Product ID
S-KO-19202
Gene Alias
Gm25206
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
10
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Snord59aem1/Cya mice (Catalog S-KO-19202) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000082844
NCBI RefSeq
XR_004936572
Target Region
Exon 1
Size of Effective Region
~140 bp
Detailed Document
Overview of Gene Research
Snord59a is a small nucleolar RNA with a C/D motif. Small nucleolar RNAs are noncoding RNAs known to regulate ribosomal RNA assembly and function [2].
In the context of anaphylaxis, the gene Snord59a was found to be significantly up-regulated in severe anaphylaxis compared to healthy controls, suggesting its potential involvement in the pathogenesis of anaphylaxis [1].
In human prostaspheres, exposure to bisphenol A (BPA) epigenetically regulated Snord59a via histone modification, and its expression was reduced in prostate cancer compared with adjacent normal tissue [2].
In summary, Snord59a is involved in ribosomal RNA-related functions. Its up-regulation in anaphylaxis and down-regulation in prostate cancer due to BPA-induced histone modification suggest its importance in these disease conditions. The study of Snord59a provides insights into the pathogenesis of anaphylaxis and the epigenetic regulation in prostate cancer [1,2].
References：
1. McGrath, Francesca Marina, Francis, Abbie, Fatovich, Daniel M, Woo, Andrew, Bosio, Erika. 2021. Small nucleolar RNA networks are up-regulated during human anaphylaxis. In Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 51, 1310-1321. doi:10.1111/cea.13982. https://pubmed.ncbi.nlm.nih.gov/34228845/
2. Ho, Shuk-Mei, Cheong, Ana, Lam, Hung-Ming, Leung, Yuet-Kin, Prins, Gail S. 2015. Exposure of Human Prostaspheres to Bisphenol A Epigenetically Regulates SNORD Family Noncoding RNAs via Histone Modification. In Endocrinology, 156, 3984-95. doi:10.1210/en.2015-1067. https://pubmed.ncbi.nlm.nih.gov/26248216/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen