C57BL/6JCya-Pzpem1/Cya
Common Name:
Pzp-KO
Product ID:
S-KO-19235
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Pzp-KO
Strain ID
KOCMP-11287-Pzp-B6J-VB
Gene Name
Product ID
S-KO-19235
Gene Alias
A1m; A2m; MAM
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Pzpem1/Cya mice (Catalog S-KO-19235) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000112132
NCBI RefSeq
NM_007376
Target Region
Exon 5~6
Size of Effective Region
~1.5 kb
Detailed Document
Overview of Gene Research
Pzp, or Pregnancy zone protein, is a member of the proteinase inhibitor I39 (α -2 -macroglobulin) family of proteins [3]. It was originally identified as a protease inhibitor but may also function as a modulator of T -helper cells and/or extracellular chaperone [1]. Pzp is elevated in normal pregnancy and numerous other inflammatory states, and is involved in extracellular proteostasis and immunoregulation [1]. Reduced levels of Pzp are associated with preeclampsia, a major cause of maternal and foetal mortality and morbidity [1]. Pzp is also associated with the development of placenta, remodeling of uterine spiral arteries, and maintenance of proteostasis in pregnancy serum [2].
In hepatocellular carcinoma (HCC), the gene encoding Pzp is hypermethylated and expressed at low levels, and Pzp markedly inhibits the proliferation, invasion and migration of HCC cells [3]. In preeclampsia and HELLP syndrome patients, Pzp expression is significantly downregulated in the syncytiotrophoblast and extravillous trophoblast of the placenta [4].
In conclusion, Pzp is a multifunctional protein important in normal pregnancy and in preventing diseases such as preeclampsia. Its role in tumor development, especially in hepatocellular carcinoma, also indicates its significance in cancer-related research. The study of Pzp through genetic models could provide insights into the pathogenesis of these diseases, offering potential for new therapeutic strategies.
References:
1. Wyatt, Amy R, Cater, Jordan H, Ranson, Marie. 2016. PZP and PAI-2: Structurally-diverse, functionally similar pregnancy proteins? In The international journal of biochemistry & cell biology, 79, 113-117. doi:10.1016/j.biocel.2016.08.018. https://pubmed.ncbi.nlm.nih.gov/27554634/
2. Tyrmi, Jaakko S, Kaartokallio, Tea, Lokki, A Inkeri, Kere, Juha, Laivuori, Hannele. . Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy. In JAMA cardiology, 8, 674-683. doi:10.1001/jamacardio.2023.1312. https://pubmed.ncbi.nlm.nih.gov/37285119/
3. Wu, Minhua, Lan, Hui, Ye, Zhongwei, Wang, Yonghui. 2021. Hypermethylation of the PZP gene is associated with hepatocellular carcinoma cell proliferation, invasion and migration. In FEBS open bio, 11, 826-832. doi:10.1002/2211-5463.13093. https://pubmed.ncbi.nlm.nih.gov/33471436/
4. Löb, Sanja, Vattai, Aurelia, Kuhn, Christina, Mahner, Sven, Jeschke, Udo. 2022. The Pregnancy Zone Protein (PZP) is significantly downregulated in the placenta of preeclampsia and HELLP syndrome patients. In Journal of reproductive immunology, 153, 103663. doi:10.1016/j.jri.2022.103663. https://pubmed.ncbi.nlm.nih.gov/35843132/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen