C57BL/6JCya-Timm17bem1/Cya
Common Name:
Timm17b-KO
Product ID:
S-KO-19369
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Timm17b-KO
Strain ID
KOCMP-21855-Timm17b-B6J-VB
Gene Name
Product ID
S-KO-19369
Gene Alias
17kDa; Sfc3; mTim17b
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
X
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Timm17bem1/Cya mice (Catalog S-KO-19369) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000033498
NCBI RefSeq
NM_011591
Target Region
Exon 3
Size of Effective Region
~0.7 kb
Detailed Document
Overview of Gene Research
TIMM17B, a gene encoding a protein involved in mitochondrial protein import, is crucial for the proper functioning of mitochondria. It is one of the paralogs in the human genome related to the yeast Tim17, and is part of the TIM23 protein translocase complex, which facilitates the transport of mitochondrial precursor proteins to the mitochondrial matrix and inner membrane [3,4]. Mitochondrial protein import pathways are essential for mitochondrial function and overall cellular homeostasis.
In breast cancer, TIMM17B shows significantly increased expression compared to paracancer tissues, and can serve as a diagnostic index and a potential immunotherapy target. Its high expression is associated with better prognosis in basal breast cancer patients. Also, TIMM17B expression is negatively correlated with immune infiltration, Tcm cells, T helper cells, and immune targets, and is significantly related to drug resistance and ferroptosis-related key enzymes expression [1].
In heart failure patients with ischemic and dilated cardiomyopathy, TIMM17B is downregulated, indicating a potential role in mitochondrial quality control, which is crucial for maintaining normal mitochondrial function [2]. In degenerative ascending aortic aneurysm, downregulation of TIMM17B was detected, suggesting its possible involvement in mitochondrial dysfunction-related aortic diseases [5].
In summary, TIMM17B plays an important role in mitochondrial-related functions. Its abnormal expression is associated with diseases such as breast cancer, heart failure, and degenerative ascending aortic aneurysm. Understanding TIMM17B through studies in these disease contexts helps to clarify its biological functions and may provide insights into disease mechanisms and potential therapeutic strategies.
References：
1. . 2023. High Expression of TIMM17B Is a Potential Diagnostic and Prognostic Marker of Breast Cancer. In Cellular and molecular biology (Noisy-le-Grand, France), 69, 169-176. doi:10.14715/cmb/2023.69.3.25. https://pubmed.ncbi.nlm.nih.gov/37300670/
2. Svagusa, T, Sikiric, S, Milavic, M, Bakovic, P, Sedlic, F. 2023. Heart failure in patients is associated with downregulation of mitochondrial quality control genes. In European journal of clinical investigation, 53, e14054. doi:10.1111/eci.14054. https://pubmed.ncbi.nlm.nih.gov/37403271/
3. Elancheliyan, Praveenraj, Maruszczak, Klaudia K, Serwa, Remigiusz Adam, Wasilewski, Michal, Chacinska, Agnieszka. 2024. OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase. In Cell reports, 43, 115038. doi:10.1016/j.celrep.2024.115038. https://pubmed.ncbi.nlm.nih.gov/39630581/
4. Maruszczak, Klaudia K, Draczkowski, Piotr, Wnorowski, Artur, Chacinska, Agnieszka. 2024. Structure prediction analysis of human core TIM23 complex reveals conservation of the protein translocation mechanism. In FEBS open bio, 14, 1656-1667. doi:10.1002/2211-5463.13840. https://pubmed.ncbi.nlm.nih.gov/38837610/
5. Almendra-Pegueros, Rafael, Barros-Membrilla, Antonio J, Pérez-Marlasca, Elvira, Rodriguez, Cristina, Galán, María. 2024. Identification of new therapeutic targets related to endoplasmic reticulum stress and mitochondrial dysfunction to reduce the risk of rupture in degenerative ascending aortic aneurysm. In Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis, , . doi:10.1016/j.arteri.2024.09.002. https://pubmed.ncbi.nlm.nih.gov/39424523/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen