C57BL/6JCya-Eva1cem1/Cya
Common Name:
Eva1c-KO
Product ID:
S-KO-19372
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Eva1c-KO
Strain ID
KOCMP-70967-Eva1c-B6J-VC
Gene Name
Product ID
S-KO-19372
Gene Alias
1700092M14Rik; 4931408A02Rik; Fam176c
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
16
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Eva1cem1/Cya mice (Catalog S-KO-19372) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000037539
NCBI RefSeq
NM_001199210
Target Region
Exon 3
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
EVA1C, also known as eva-1 homolog C, is a gene with multiple functions. It is a novel Slit receptor, and its expression pattern is consistent with an axon guidance role in the mouse nervous system, playing a part in the formation of neural circuitry [3]. It may also be involved in the Wnt signaling pathway, as a switch from noncanonical to canonical Wnt signaling activates EVA1C to inhibit neuroblast migration [4].
In terms of disease-related findings, in WHO grade II/III glioma, high EVA1C expression is associated with malignant clinicopathological features and poor overall survival, and it is positively associated with immune infiltration levels of multiple immune cells, suggesting it could be a potential prognostic biomarker and a predictor of high immune infiltration [1]. In neonatal hypoxic-ischemic encephalopathy (NHIE), the expression of EVA1C is upregulated in relevant cell models. Silencing EVA1C can increase cell survival and growth, potentially associated with alternative splicing, indicating its potential as a therapeutic target for NHIE [2].
In conclusion, EVA1C has important functions in neural development and may play a role in multiple disease conditions. Studies on EVA1C contribute to our understanding of neural circuit formation, glioma prognosis, and the mechanism of NHIE, providing potential directions for disease diagnosis, prognosis prediction, and treatment.
References:
1. Hu, Zhicheng, Qu, Shanqiang. 2021. EVA1C Is a Potential Prognostic Biomarker and Correlated With Immune Infiltration Levels in WHO Grade II/III Glioma. In Frontiers in immunology, 12, 683572. doi:10.3389/fimmu.2021.683572. https://pubmed.ncbi.nlm.nih.gov/34267752/
2. Hu, Yue, Rong, Rong, Wang, Yi, Liu, Su, Wang, Lei. 2022. Downregulating EVA1C exerts the potential to promote neuron growth after neonatal hypoxic-ischemic encephalopathy injury associated with alternative splicing. In Ibrain, 8, 481-491. doi:10.1002/ibra.12053. https://pubmed.ncbi.nlm.nih.gov/37786591/
3. James, Gregory, Foster, Simon R, Key, Brian, Beverdam, Annemiek. 2013. The expression pattern of EVA1C, a novel Slit receptor, is consistent with an axon guidance role in the mouse nervous system. In PloS one, 8, e74115. doi:10.1371/journal.pone.0074115. https://pubmed.ncbi.nlm.nih.gov/24040182/
4. Rella, Lorenzo, Fernandes Póvoa, Euclides E, Mars, Jonas, Betist, Marco C, Korswagen, Hendrik C. . A switch from noncanonical to canonical Wnt signaling stops neuroblast migration through a Slt-Robo and RGA-9b/ARHGAP-dependent mechanism. In Proceedings of the National Academy of Sciences of the United States of America, 118, . doi:10.1073/pnas.2013239118. https://pubmed.ncbi.nlm.nih.gov/33737394/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen