C57BL/6JCya-Tprg1lem1/Cya
Common Name:
Tprg1l-KO
Product ID:
S-KO-19399
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Tprg1l-KO
Strain ID
KOCMP-67808-Tprg1l-B6J-VB
Gene Name
Product ID
S-KO-19399
Gene Alias
1200015A19Rik; Svap30; Tprgl; mover
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
4
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tprg1lem1/Cya mice (Catalog S-KO-19399) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000030896
NCBI RefSeq
NM_026388
Target Region
Exon 3
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
Tprg1l, also known as Mover, is a protein-coding gene. It has multiple functions including regulating the probability of neurotransmitter release in neurons, being associated with lipid droplets in astrocytes, and participating in signaling pathways like NF-κB [2,5,6,7]. It seems to play a role in lipid-related neurological disorders and may be involved in cellular inflammatory responses [2,3].
In gallbladder cancer, tRF-3013b inhibits cell proliferation by targeting Tprg1l and repressing NF-κB. Decreased tRF-3013b expression is correlated with poor overall survival in GBC patients [1]. In the context of human cytomegalovirus infection, the long non-coding RNA1.2 suppresses extracellular release of the pro-inflammatory cytokine IL-6 by blocking NF-κB activation, and Tprg1L upregulation activates NF-κB, leading to increased IL-6 expression [4].
In conclusion, Tprg1l is involved in multiple biological processes such as synaptic transmission, lipid droplet regulation in astrocytes, and inflammatory responses. Its role in diseases like gallbladder cancer and during viral infections, as revealed through functional studies, highlights its importance in understanding disease mechanisms and potentially developing new therapeutic strategies.
References:
1. Zou, Lu, Yang, Yang, Zhou, Biyu, Bao, Runfa, Liu, Yingbin. 2022. tRF-3013b inhibits gallbladder cancer proliferation by targeting TPRG1L. In Cellular & molecular biology letters, 27, 99. doi:10.1186/s11658-022-00398-6. https://pubmed.ncbi.nlm.nih.gov/36401185/
2. Krohn, Jeremy, Domart, Florelle, Do, Thanh Thao, Dresbach, Thomas. 2023. The synaptic vesicle protein Mover/TPRG1L is associated with lipid droplets in astrocytes. In Glia, 71, 2799-2814. doi:10.1002/glia.24452. https://pubmed.ncbi.nlm.nih.gov/37539560/
3. Liu, Haiying, Yang, Yiding, Ge, Yuanlong, Liu, Juanhong, Zhao, Yong. . TERC promotes cellular inflammatory response independent of telomerase. In Nucleic acids research, 47, 8084-8095. doi:10.1093/nar/gkz584. https://pubmed.ncbi.nlm.nih.gov/31294790/
4. Lau, Betty, Kerr, Karen, Gu, Quan, Weekes, Michael P, Davison, Andrew J. 2020. Human Cytomegalovirus Long Non-coding RNA1.2 Suppresses Extracellular Release of the Pro-inflammatory Cytokine IL-6 by Blocking NF-κB Activation. In Frontiers in cellular and infection microbiology, 10, 361. doi:10.3389/fcimb.2020.00361. https://pubmed.ncbi.nlm.nih.gov/32793512/
5. Körber, Christoph, Horstmann, Heinz, Venkataramani, Varun, Dresbach, Thomas, Kuner, Thomas. 2015. Modulation of Presynaptic Release Probability by the Vertebrate-Specific Protein Mover. In Neuron, 87, 521-33. doi:10.1016/j.neuron.2015.07.001. https://pubmed.ncbi.nlm.nih.gov/26212709/
6. Ahmed, Saheeb, Wittenmayer, Nina, Kremer, Thomas, Dean, Camin, Dresbach, Thomas. 2013. Mover is a homomeric phospho-protein present on synaptic vesicles. In PloS one, 8, e63474. doi:10.1371/journal.pone.0063474. https://pubmed.ncbi.nlm.nih.gov/23723986/
7. Kremer, Thomas, Kempf, Christian, Wittenmayer, Nina, Kirsch, Joachim, Dresbach, Thomas. 2007. Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses. In FEBS letters, 581, 4727-33. doi:. https://pubmed.ncbi.nlm.nih.gov/17869247/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen