C57BL/6JCya-Rgs1em1/Cya
Common Name:
Rgs1-KO
Product ID:
S-KO-19415
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Rgs1-KO
Strain ID
KOCMP-50778-Rgs1-B6J-VB
Gene Name
Product ID
S-KO-19415
Gene Alias
BL34
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
1
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rgs1em1/Cya mice (Catalog S-KO-19415) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000189061
NCBI RefSeq
NM_015811
Target Region
Exon 4
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Rgs1, short for Regulator of G-protein signaling 1, is a gene involved in multiple biological processes. It plays a role in regulating G-protein-coupled receptor (GPCR) signaling, which is crucial for many cellular functions such as signal transduction, cell-cell communication, and immune responses [4].
In various disease contexts, research has shown its significance. In acute lung injury/acute respiratory distress syndrome (ALI/ARDS) and pulmonary fibrosis (PF), exosomes from vascular endothelial cells and type II alveolar epithelial cells target RGS1 to regulate the immunophenotype of alveolar macrophages through the PLC-IP3R signal-dependent intracellular Ca2+ response [1]. In renal interstitial fibrosis (RIF), knockdown of RGS1 inhibited renal cell inflammatory response, fibrosis, and renal fibrosis in mouse models, indicating its role in promoting RIF through activation of the inflammatory response [2]. In cervical and gastric cancer, knockdown of RGS1 inhibited cell proliferation, migration, invasion, and tumor growth in nude mice, suggesting it may act as an oncogenic gene [3,5]. In spinal cord injury, silencing RGS1 suppressed the TLR-induced inflammation and improved spinal cord histology and function recovery via the TLR/TRIF/NF-κB signaling pathway [6].
In conclusion, Rgs1 is a key regulator in multiple biological processes and disease conditions. Studies using gene-knockout or knockdown models in mice have revealed its role in inflammation, fibrosis, and cancer progression. Understanding Rgs1 provides potential therapeutic targets for diseases like ALI/ARDS, PF, RIF, and certain cancers.
References:
1. Feng, Zunyong, Zhou, Jing, Liu, Yinhua, Wang, Yongsheng, Xia, Hongping. 2021. Epithelium- and endothelium-derived exosomes regulate the alveolar macrophages by targeting RGS1 mediated calcium signaling-dependent immune response. In Cell death and differentiation, 28, 2238-2256. doi:10.1038/s41418-021-00750-x. https://pubmed.ncbi.nlm.nih.gov/33753901/
2. Lu, Tefei, Chen, Sheng, Xu, Jianting. 2023. RGS1 mediates renal interstitial fibrosis through activation of the inflammatory response. In Archives of biochemistry and biophysics, 750, 109744. doi:10.1016/j.abb.2023.109744. https://pubmed.ncbi.nlm.nih.gov/37696381/
3. Zhang, Siyang, Wang, Han, Liu, Jiao, Zeng, Zhi, Wang, Min. 2022. RGS1 and related genes as potential targets for immunotherapy in cervical cancer: computational biology and experimental validation. In Journal of translational medicine, 20, 334. doi:10.1186/s12967-022-03526-0. https://pubmed.ncbi.nlm.nih.gov/35879796/
4. Yamada, Chiharu, Okada, Kentaro, Odaira, Koya, Kiyoi, Hitoshi, Hayakawa, Fumihiko. . RGS1 and CREB5 are direct and common transcriptional targets of ZNF384-fusion proteins. In Cancer medicine, 13, e7471. doi:10.1002/cam4.7471. https://pubmed.ncbi.nlm.nih.gov/39015025/
5. Chen, Zhixiong, Liu, Banglun, Zhang, Shouru, Lv, Yuyu, Sun, Hao. 2022. RGS1 serves as an antitumor target to inhibit proliferation of NICN87-DR cells and tumor growth in the gastric cancer mouse model. In Turkish journal of biology = Turk biyoloji dergisi, 46, 277-287. doi:10.55730/1300-0152.2616. https://pubmed.ncbi.nlm.nih.gov/37529094/
6. Feng, Dongqian, Yu, Jiasheng, Bao, Lei, Fan, Daobo, Zhang, Bin. 2021. Inhibiting RGS1 attenuates secondary inflammation response and tissue degradation via the TLR/TRIF/NF-κB pathway in macrophage post spinal cord injury. In Neuroscience letters, 768, 136374. doi:10.1016/j.neulet.2021.136374. https://pubmed.ncbi.nlm.nih.gov/34852285/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen