C57BL/6JCya-Slc22a1em1/Cya
Common Name:
Slc22a1-KO
Product ID:
S-KO-19419
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Slc22a1-KO
Strain ID
KOCMP-20517-Slc22a1-B6J-VD
Gene Name
Product ID
S-KO-19419
Gene Alias
Lx1; Oct1; Orct; Orct1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
17
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc22a1em1/Cya mice (Catalog S-KO-19419) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000024596
NCBI RefSeq
NM_009202
Target Region
Exon 4
Size of Effective Region
~1.9 kb
Detailed Document
Overview of Gene Research
Slc22a1, also known as the gene encoding the organic cation transporter 1 (hOCT1), is a significant member of the SLC22 transporter family. hOCT1 is expressed in most epithelial barriers and different drug target cells, contributing to drug pharmacokinetics and pharmacodynamics. It mediates the translocation of various drugs and is involved in multiple biological processes [2].
In chronic myeloid leukemia (CML), carriers of SLC22A1 rs628031A allele or rs683369G allele were associated with a lower major molecular response (MMR) rate when treated with imatinib [1]. In the context of drug disposition, SLC22A1 polymorphisms have an impact on metformin clinical parameters, such as affecting the area under the concentration-time curve, Cmax, and responsiveness [2]. In Mexican women, genetic variants in SLC22A1 were related to serum lipid levels, with certain genotypes and haplotypes associated with elevated cholesterol, LDL-c, and HDL-c levels [3]. In children with acute lymphoblastic leukemia in the Amazon region, the SLC22A1 gene variant was associated with a higher risk of severe infectious toxicity during treatment [4].
In conclusion, Slc22a1 plays a crucial role in drug transport and disposition, influencing the efficacy and toxicity of drugs in various disease conditions like CML, diabetes, and leukemia. Its genetic variants also have an impact on lipid metabolism. The study of Slc22a1 helps in understanding the role of drug transporters in disease treatment and the influence of genetic factors on drug response.
References:
1. Cargnin, Sarah, Ravegnini, Gloria, Soverini, Simona, Angelini, Sabrina, Terrazzino, Salvatore. 2018. Impact of SLC22A1 and CYP3A5 genotypes on imatinib response in chronic myeloid leukemia: A systematic review and meta-analysis. In Pharmacological research, 131, 244-254. doi:10.1016/j.phrs.2018.02.005. https://pubmed.ncbi.nlm.nih.gov/29427770/
2. Arimany-Nardi, C, Koepsell, H, Pastor-Anglada, M. 2015. Role of SLC22A1 polymorphic variants in drug disposition, therapeutic responses, and drug-drug interactions. In The pharmacogenomics journal, 15, 473-87. doi:10.1038/tpj.2015.78. https://pubmed.ncbi.nlm.nih.gov/26526073/
3. Cahua-Pablo, José Ángel, Gómez-Zamudio, Jaime Héctor, Reséndiz-Abarca, Carlos Alberto, Zubillaga-Guerrero, Ma Isabel, Flores-Alfaro, Eugenia. 2021. Genetic variants in SLC22A1 are related to serum lipid levels in Mexican women. In Lipids, 57, 105-114. doi:10.1002/lipd.12334. https://pubmed.ncbi.nlm.nih.gov/34927264/
4. Fernandes, Sweny de S M, Leitão, Luciana P C, Cohen-Paes, Amanda de N, Santos, Sidney E B Dos, Santos, Ney P C Dos. 2022. The Role of SLC22A1 and Genomic Ancestry on Toxicity during Treatment in Children with Acute Lymphoblastic Leukemia of the Amazon Region. In Genes, 13, . doi:10.3390/genes13040610. https://pubmed.ncbi.nlm.nih.gov/35456416/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen