C57BL/6JCya-Cipcem1/Cya
Common Name:
Cipc-KO
Product ID:
S-KO-19420
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Cipc-KO
Strain ID
KOCMP-217732-Cipc-B6J-VC
Gene Name
Product ID
S-KO-19420
Gene Alias
2310044G17Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
12
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cipcem1/Cya mice (Catalog S-KO-19420) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000038369
NCBI RefSeq
NM_173735
Target Region
Exon 3
Size of Effective Region
~2.0 kb
Detailed Document
Overview of Gene Research
CipC, or CLOCK-interacting protein Circadian, is a negative-feedback regulator of the circadian clock. It is involved in various biological processes. In mammals, it has been associated with the regulation of the circadian clock machinery, and it may also play a role in cell cycle regulation through interactions with proteins like CAD and Erk [3,4].
Specific deletion of Cipc in satellite cells of mdx mice alleviates myopathy, improves muscle function, and reduces fibrosis. Cipc deficiency activates the ERK1/2 and JNK1/2 signaling pathways, which in turn activates the transcription factor SP1 to trigger the transcription of Pax7 and MyoD, promoting muscle regeneration [1]. In mice, inactivation of Cipc alters the expression of Per1 but does not affect circadian rhythms [2].
In conclusion, CipC plays a role as a negative regulator in satellite cell function and may have implications in muscle-related diseases as demonstrated by Cipc-deficient mouse models. Additionally, while it impacts the expression of certain clock-related genes, it is not critically required for basic circadian clock function in mice.
References：
1. Zheng, Jiqing, Lou, Jing, Li, Yanfang, Li, Yangxin, Song, Yao-Hua. . Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice. In Cell reports, 39, 110939. doi:10.1016/j.celrep.2022.110939. https://pubmed.ncbi.nlm.nih.gov/35705041/
2. Qu, ZhiPeng, Wang, XiaoHan, Liu, DongChuan, Gao, Xiang, Xu, Ying. 2015. Inactivation of Cipc alters the expression of Per1 but not circadian rhythms in mice. In Science China. Life sciences, 58, 368-72. doi:10.1007/s11427-015-4828-1. https://pubmed.ncbi.nlm.nih.gov/25862660/
3. Zhao, Wen-Ning, Malinin, Nikolay, Yang, Fu-Chia, Kramer, Achim, Weitz, Charles J. 2007. CIPC is a mammalian circadian clock protein without invertebrate homologues. In Nature cell biology, 9, 268-75. doi:. https://pubmed.ncbi.nlm.nih.gov/17310242/
4. Matsunaga, Ryota, Nishino, Tasuku, Yokoyama, Atsushi, Kikkawa, Ushio, Konishi, Hiroaki. 2015. Versatile function of the circadian protein CIPC as a regulator of Erk activation. In Biochemical and biophysical research communications, 469, 377-83. doi:10.1016/j.bbrc.2015.11.117. https://pubmed.ncbi.nlm.nih.gov/26657846/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen