C57BL/6JCya-Slc23a4em1/Cya
Common Name
Slc23a4-KO
Product ID
S-KO-19428
Backgroud
C57BL/6JCya
Strain ID
KOCMP-243753-Slc23a4-B6J-VC
Status
When using this mouse strain in a publication, please cite “Slc23a4-KO Mouse (Catalog S-KO-19428) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Slc23a4-KO
Strain ID
KOCMP-243753-Slc23a4-B6J-VC
Gene Name
Product ID
S-KO-19428
Gene Alias
Gm468, 2010107G12Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 6
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000044387
NCBI RefSeq
NM_001025573
Target Region
Exon 4
Size of Effective Region
~1.9 kb
Overview of Gene Research
Slc23a4, also known as sodium-dependent nucleobase transporter 1 (SNBT1), is a key gene involved in the intestinal absorption of nucleobases and their analogs in non-primate animals. It codes for a sodium-dependent carrier-mediated transport system at the brush border membrane of epithelial cells in the small intestine, which is crucial for the uptake of compounds like uracil, thymine, guanine, hypoxanthine, and xanthine [2,3].
In mice, studies on gene-targeted Slc23a4-deficient models have shown significant implications. For example, in Xdh-deficient mice, pseudogenization of Slc23a4 (Slc23a4 -/-) in combination with high Hprt activity (Hprt(high)Xdh(- / -)Slc23a4(- / -) mice) led to a longer lifespan and reaching adulthood, although they still exhibited renal impairment, high plasma creatinine levels, and anemia. Female Hprt(high)Xdh(- / -)Slc23a4(- / -) mice produced non-surviving offspring. This indicates that Slc23a4 plays a role in the survival and renal function of Xdh-deficient mice [1].
In conclusion, Slc23a4 is essential for the intestinal absorption of nucleobases in non-primate animals. The study of Slc23a4-deficient mouse models has provided insights into its role in the survival and renal function of Xdh-deficient mice, contributing to our understanding of related disease conditions such as type 1 xanthinuria-like phenotypes in mice [1].
References：
1. Terada, Kazuki, Watanabe, Tamaki, Yasuno, Nobuhiro, Ichida, Kimiyoshi, Hosoyamada, Makoto. 2025. Pseudogenization of the Slc23a4 gene is necessary for the survival of Xdh-deficient mice. In Scientific reports, 15, 3250. doi:10.1038/s41598-025-87751-9. https://pubmed.ncbi.nlm.nih.gov/39863758/
2. Yuasa, Hiroaki, Yasujima, Tomoya, Inoue, Katsuhisa. . Current Understanding of the Intestinal Absorption of Nucleobases and Analogs. In Biological & pharmaceutical bulletin, 43, 1293-1300. doi:10.1248/bpb.b20-00342. https://pubmed.ncbi.nlm.nih.gov/32879202/
3. Yamamoto, Syunsuke, Inoue, Katsuhisa, Murata, Tomoaki, Ohta, Kin-ya, Yuasa, Hiroaki. 2009. Identification and functional characterization of the first nucleobase transporter in mammals: implication in the species difference in the intestinal absorption mechanism of nucleobases and their analogs between higher primates and other mammals. In The Journal of biological chemistry, 285, 6522-31. doi:10.1074/jbc.M109.032961. https://pubmed.ncbi.nlm.nih.gov/20042597/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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