C57BL/6JCya-D6Wsu163eem1/Cya
Common Name:
D6Wsu163e-KO
Product ID:
S-KO-19429
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
D6Wsu163e-KO
Strain ID
KOCMP-28040-D6Wsu163e-B6J-VC
Gene Name
Product ID
S-KO-19429
Gene Alias
C12orf4
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-D6Wsu163eem1/Cya mice (Catalog S-KO-19429) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000032497
NCBI RefSeq
NM_138594
Target Region
Exon 4
Size of Effective Region
~1.5 kb
Detailed Document
Overview of Gene Research
D6Wsu163e is a murine gene. However, no human ortholog has been found for it [1].
A study aimed to identify pathogenic and likely pathogenic variants in novel human-mouse ortholog genes related to non-syndromic hearing impairment (NSHI). In this research, D6Wsu163e was among 4 murine genes out of 38 that lacked human orthologs [1].
In conclusion, while D6Wsu163e has no identified human ortholog, the study of this murine gene in the context of NSHI research helps in understanding the genetic architecture of hearing impairment in the mouse model, which may potentially offer insights into the overall genetic mechanisms related to hearing function, despite the lack of a direct human equivalent [1].
References：
1. Oluwole, Oluwafemi G, Esoh, Kevin K, Wonkam-Tingang, Edmond, Chimusa, Emile R, Wonkam, Ambroise. 2020. Whole exome sequencing identifies rare coding variants in novel human-mouse ortholog genes in African individuals diagnosed with non-syndromic hearing impairment. In Experimental biology and medicine (Maywood, N.J.), 246, 197-206. doi:10.1177/1535370220960388. https://pubmed.ncbi.nlm.nih.gov/32996353/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen