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C57BL/6JCya-Sbk1em1/Cya
Common Name:
Sbk1-KO
Product ID:
S-KO-19439
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Sbk1-KO
Strain ID
KOCMP-104175-Sbk1-B6J-VC
Gene Name
Sbk1
Product ID
S-KO-19439
Gene Alias
Sbk
Background
C57BL/6JCya
NCBI ID
104175
Modification
Conventional knockout
Chromosome
7
Phenotype
MGI:2135937
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Sbk1em1/Cya mice (Catalog S-KO-19439) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000056028
NCBI RefSeq
NM_145587
Target Region
Exon 3
Size of Effective Region
~0.9 kb
Detailed Document
Click here to download >>
Overview of Gene Research
SBK1, also known as SH3 domain binding kinase 1, is a serine/threonine kinase belonging to the new kinase family (NFK). It has been implicated in various biological processes such as memory formation, lipid metabolism, and cancer cell progression [1]. It may be involved in multiple signaling pathways, and its expression is regulated by hormones and nutrients [1].

In terms of lipid metabolism, SBK1 is a regulator of hepatic lipid metabolism and systemic insulin sensitivity in response to obesity. Liver-specific SBK1 knockout (Lsko) mice fed a high-fat diet (HFD) displayed more severe hepatosteatosis, higher expression of genes in fatty acid uptake and lipogenesis, symptoms of hyperglycemia, poor systemic glucose tolerance, and lower insulin sensitivity compared to control mice. On the other hand, hepatic SBK1 overexpression alleviated high-fructose diet-induced hepatosteatosis, hyperlipidemia, and hyperglycemia in mice [2].

In cancer, in cervical cancer, SBK1 promotes proliferation and inhibits apoptosis via activating the Wnt/β-catenin and Raf/ERK1/2 signaling pathways. Stable SBK1-knockdown in cervical cancer cells suppressed their proliferative, migratory, and invasive capacities and enhanced apoptosis [3].

In conclusion, SBK1 plays a crucial role in lipid metabolism, protecting against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway. In cancer, it can promote cancer cell survival and proliferation in certain types such as cervical cancer. The use of gene knockout mouse models, like the liver-specific SBK1 knockout mice, has been instrumental in revealing its functions in these biological processes and disease conditions.

References:
1. Hang, Miaojia, Tse, Margaret Chui Ling, Pang, Brian Pak Shing, Wong, Anderson O L, Chan, Chi Bun. 2023. Differential regulation of hepatic SH3 domain binding kinase 1 (SBK1) expression in mouse and goldfish. In General and comparative endocrinology, 344, 114372. doi:10.1016/j.ygcen.2023.114372. https://pubmed.ncbi.nlm.nih.gov/37652166/
2. Ahuja, Palak, Bi, Xinyi, Ng, Chun Fai, Lee, Chi Wai, Chan, Chi Bun. 2022. Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway. In Hepatology (Baltimore, Md.), 77, 213-229. doi:10.1002/hep.32501. https://pubmed.ncbi.nlm.nih.gov/35363898/
3. Chen, Xin, Sun, Zhengwei, Zhou, Shengjie, Song, Gendi, Zhu, Xueqiong. 2023. SH3 domain-binding kinase 1 promotes proliferation and inhibits apoptosis of cervical cancer via activating the Wnt/β-catenin and Raf/ERK1/2 signaling pathways. In Molecular carcinogenesis, 62, 1147-1162. doi:10.1002/mc.23552. https://pubmed.ncbi.nlm.nih.gov/37132991/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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