C57BL/6JCya-Tmem185aem1/Cya
Common Name:
Tmem185a-KO
Product ID:
S-KO-19443
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Tmem185a-KO
Strain ID
KOCMP-236848-Tmem185a-B6J-VC
Gene Name
Product ID
S-KO-19443
Gene Alias
ee3
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
X
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tmem185aem1/Cya mice (Catalog S-KO-19443) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000114630
NCBI RefSeq
NM_001357750
Target Region
Exon 3
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Tmem185a, a gene of currently not well-defined primary function, may be involved in multiple biological processes related to cancer. It is potentially associated with pathways relevant to tumor metastasis and prognosis determination [1,2,3]. Its study in genetic models could offer insights into its functional mechanisms.
In breast cancer, Tmem185a is among the neoantigens specifically present in lymph node-positive samples, suggesting it could be a potential target for vaccine design to address lymph node metastasis [1].
In urinary bladder cancer, along with TMPRSS11E, SCEL, and KRT78, Tmem185a was identified as part of a four-gene signature. This signature can be used to group patients into high-risk and low-risk groups based on overall survival, and may serve as potential therapeutic targets and diagnostic markers [2].
In stage III serous ovarian carcinoma, TMEM185A was among the down-regulated genes, potentially related to the prognosis of patients [3].
In a case of severe hemophilia A, the rearrangement affected the copy number of TMEM185A along with other genes, though its dosage-dependent biological effects were not clinically detectable other than hemophilia A [4].
In conclusion, Tmem185a appears to be associated with cancer-related processes such as metastasis and prognosis in breast, urinary bladder, and ovarian cancers. Its role in these diseases indicates the potential importance of studying Tmem185a in relevant genetic models, which could provide a better understanding of cancer mechanisms and potentially lead to new treatment strategies.
References:
1. Wang, Zhigang, Liu, Wei, Chen, Chong, Luo, Yunping, Zhang, Bailin. 2019. Low mutation and neoantigen burden and fewer effector tumor infiltrating lymphocytes correlate with breast cancer metastasization to lymph nodes. In Scientific reports, 9, 253. doi:10.1038/s41598-018-36319-x. https://pubmed.ncbi.nlm.nih.gov/30670769/
2. Chen, Siteng, Zhang, Ning, Shao, Jialiang, Wang, Tao, Wang, Xiang. 2019. A novel gene signature combination improves the prediction of overall survival in urinary bladder cancer. In Journal of Cancer, 10, 5744-5753. doi:10.7150/jca.30307. https://pubmed.ncbi.nlm.nih.gov/31737111/
3. Kim, Yun-Sook, Hwan, Jin Do, Bae, Sumi, Bae, Dong-Han, Shick, Woong Ahn. 2010. Identification of differentially expressed genes using an annealing control primer system in stage III serous ovarian carcinoma. In BMC cancer, 10, 576. doi:10.1186/1471-2407-10-576. https://pubmed.ncbi.nlm.nih.gov/20969748/
4. Sheen, Campbell R, Jewell, Ursula R, Morris, Christine M, Smith, Mark P, Chen, Jian-Min. . Double complex mutations involving F8 and FUNDC2 caused by distinct break-induced replication. In Human mutation, 28, 1198-206. doi:. https://pubmed.ncbi.nlm.nih.gov/17683067/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen