C57BL/6JCya-Zswim2em1/Cya
Common Name
Zswim2-KO
Product ID
S-KO-19445
Backgroud
C57BL/6JCya
Strain ID
KOCMP-71861-Zswim2-B6J-VC
Status
When using this mouse strain in a publication, please cite “Zswim2-KO Mouse (Catalog S-KO-19445) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Zswim2-KO
Strain ID
KOCMP-71861-Zswim2-B6J-VC
Gene Name
Product ID
S-KO-19445
Gene Alias
MEX, 1700025P14Rik, 4933437F18Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000038223
NCBI RefSeq
NM_027964
Target Region
Exon 4
Size of Effective Region
~0.8 kb
Overview of Gene Research
Zswim2, Zinc finger SWIM-type containing 2, is a testis-specific E3 ubiquitin-protein ligase. Ubiquitination is a crucial post-translational modification for protein homeostasis, and Zswim2 likely functions in related regulatory pathways [1].
Using the CRISPR/Cas9 system to generate Zswim2 knockout (KO) mice, it was found that male fertility, male reproductive organ, and sperm-associated parameters were largely unaffected in Zswim2 KO males. This indicates that Zswim2 may not be essential for these aspects of male reproduction [1].
In conclusion, Zswim2, as a testis-specific E3 ubiquitin-protein ligase, does not seem to have a critical impact on male fertility and related reproductive parameters based on Zswim2 KO mouse model studies. However, further research may be needed to fully understand its potential functions in other biological processes or under different conditions [1].
References：
1. Nozawa, Kaori, Fujihara, Yoshitaka, Devlin, Darius J, Garcia, Thomas X, Matzuk, Martin M. 2022. The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice. In BMC biology, 20, 161. doi:10.1186/s12915-022-01368-2. https://pubmed.ncbi.nlm.nih.gov/35831855/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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