Zswim2, Zinc finger SWIM-type containing 2, is a testis-specific E3 ubiquitin-protein ligase. Ubiquitination is a crucial post-translational modification for protein homeostasis, and Zswim2 likely functions in related regulatory pathways [1].

Using the Nuclease technology system to generate Zswim2 knockout (KO) mice, it was found that male fertility, male reproductive organ, and sperm-associated parameters were largely unaffected in Zswim2 KO males. This indicates that Zswim2 may not be essential for these aspects of male reproduction [1].

In conclusion, Zswim2, as a testis-specific E3 ubiquitin-protein ligase, does not seem to have a critical impact on male fertility and related reproductive parameters based on Zswim2 KO mouse model studies. However, further research may be needed to fully understand its potential functions in other biological processes or under different conditions [1].