C57BL/6JCya-Fahd2aem1/Cya
Common Name:
Fahd2a-KO
Product ID:
S-KO-19451
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Fahd2a-KO
Strain ID
KOCMP-68126-Fahd2a-B6J-VC
Gene Name
Product ID
S-KO-19451
Gene Alias
1500003K14Rik; B430104H02Rik; Cgi-105; Fahd2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fahd2aem1/Cya mice (Catalog S-KO-19451) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000028848
NCBI RefSeq
NM_029629
Target Region
Exon 3
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
FAHD2A, one of the three mammalian FAH domain-containing proteins, has its exact function yet to be fully elucidated. FAH domain-containing proteins in both prokaryotes and eukaryotes carry out diverse enzymatic reactions related to the structure of their FAH domains [2].
In bioinformatics-based research on the causal relationship between obesity and hepatocellular carcinoma (HCC), FAHD2A was identified as one of the four differentially expressed genes common in obesity and HCC. Functional enrichment analyses indicated its potential roles in processes such as RNA capping, viral transcription, IL-17 signaling, and endocrine resistance. These genes also exhibited negative correlations with immune cell infiltration and immunotherapy markers in HCC, suggesting that they may be implicated in obesity-induced hepatocarcinogenesis through regulating cell cycle, inflammation, and immune evasion [1].
Additionally, in a study on stratifying the malignant risk of intraductal papillary mucinous neoplasm of the pancreas, FAHD2A was identified as one of the five discriminatory biomarkers with large LASSO coefficients and an AUC > 0.75 [3].
In conclusion, FAHD2A appears to be involved in multiple biological processes relevant to diseases such as HCC and pancreatic neoplasms. The findings from these studies help in understanding its role in disease-related mechanisms, potentially providing insights for further research on disease prevention and treatment.
References:
1. Chen, Zhitao, Ding, Chenchen, Chen, Kailei, Qiu, Xiaoxia, Li, Qiyong. 2024. Investigating the causal association between obesity and risk of hepatocellular carcinoma and underlying mechanisms. In Scientific reports, 14, 15717. doi:10.1038/s41598-024-66414-1. https://pubmed.ncbi.nlm.nih.gov/38977823/
2. Pircher, Haymo, von Grafenstein, Susanne, Diener, Thomas, Liedl, Klaus R, Jansen-Dürr, Pidder. 2015. Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase. In The Journal of biological chemistry, 290, 6755-62. doi:10.1074/jbc.M114.609305. https://pubmed.ncbi.nlm.nih.gov/25575590/
3. Liu, Chunliang, Mosley, Amber, Irajizad, Ehsan, Schmidt, C Max, Zhang, Jianjun. 2025. Cyst fluid proteins stratify malignant risk of intraductal papillary mucinous neoplasm of the pancreas. In Cancer letters, 624, 217753. doi:10.1016/j.canlet.2025.217753. https://pubmed.ncbi.nlm.nih.gov/40300662/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen