C57BL/6JCya-Lonrf3em1/Cya
Common Name
Lonrf3-KO
Product ID
S-KO-19462
Backgroud
C57BL/6JCya
Strain ID
KOCMP-74365-Lonrf3-B6J-VC
Status
When using this mouse strain in a publication, please cite “Lonrf3-KO Mouse (Catalog S-KO-19462) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Lonrf3-KO
Strain ID
KOCMP-74365-Lonrf3-B6J-VC
Gene Name
Product ID
S-KO-19462
Gene Alias
Rnf127, 4932412G04Rik, 5730439E01Rik, A830039N02Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000016383
NCBI RefSeq
NM_028894
Target Region
Exon 4
Size of Effective Region
~1.3 kb
Overview of Gene Research
Lonrf3, also known as a member of the E3 ubiquitin-protein ligase family, is involved in the process of ubiquitination, which plays a crucial role in regulating protein degradation, cell cycle, and various cellular signaling pathways [2]. Dysregulation of such E3 ligases can have implications for cancer development.
In breast cancer, Lonrf3 was screened as one of the prognostic signature genes related to M2-like tumor-associated macrophages (M2-like TAMs). A RiskScore model based on these genes was developed, and it was found that the mRNA expression levels of Lonrf3 were significantly different in control and breast cancer cell lines, suggesting its potential as a therapeutic target [1].
In pancreatic cancer, among differentially expressed E3 ubiquitin-protein ligase genes, Lonrf3 was identified to have prognostic significance, along with other genes and clinical parameters. This indicates its possible role in pancreatic cancer progression [2].
In conclusion, Lonrf3, as an E3 ubiquitin-protein ligase, is involved in important cellular regulatory pathways. Its differential expression in breast and pancreatic cancer cell lines suggests its potential significance in these disease areas, providing potential targets for further research and therapeutic development.
References：
1. Xu, Yanghaochen, Lin, Peiyan, Zhu, Ye, Zhang, Qing, Zhou, Jinhong. 2025. Applying integrated transcriptome and single-cell sequencing analysis to develop a prognostic signature based on M2-like tumor-associated macrophages for breast cancer. In Discover oncology, 16, 389. doi:10.1007/s12672-025-02161-7. https://pubmed.ncbi.nlm.nih.gov/40131644/
2. Feng, Lei, Wang, Jieqing, Zhang, Jianmin, Gao, Yi, Zhou, Chenjie. 2021. Comprehensive Analysis of E3 Ubiquitin Ligases Reveals Ring Finger Protein 223 as a Novel Oncogene Activated by KLF4 in Pancreatic Cancer. In Frontiers in cell and developmental biology, 9, 738709. doi:10.3389/fcell.2021.738709. https://pubmed.ncbi.nlm.nih.gov/34722520/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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