Trpc4, a member of the transient receptor potential (TRP) ion channels family, conducts cations into cells, mediating functions from neuronally mediated temperature sensation to intracellular signaling [1]. Canonical transient receptor potential (TRPC) channels are Ca2+-permeable channels involved in various diseases, and Trpc4 is expressed in diverse organs and cell types [4].

Studies on Trpc4 -deficient mice have shown its role in regulating vascular tone, endothelial permeability, gastrointestinal contractility and motility, neurotransmitter release, and social exploratory behavior, as well as in excitotoxicity and epileptogenesis [4]. In pulmonary arterial endothelial cells (PAECs), knockdown of Trpc4 attenuated hypoxia-induced apoptosis, and adeno-associated virus-mediated pulmonary endothelial Trpc4 silencing suppressed hypoxic pulmonary hypertension progression [2]. Also, silencing the Trpc4 channel in mice substantially attenuated hypothermia induced by light-mediated heating of the preoptic area, indicating its role in warm sensing and body temperature regulation [3].

In conclusion, Trpc4 is essential for functions like warm sensing, body temperature regulation, and maintaining normal physiological functions in the cardiovascular, nervous, and other systems. Its study using gene knockout mouse models has provided insights into its role in diseases such as hypoxic pulmonary hypertension, highlighting its potential as a therapeutic target in these disease areas.