C57BL/6JCya-Fuca2em1/Cya
Common Name:
Fuca2-KO
Product ID:
S-KO-19478
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Fuca2-KO
Strain ID
KOCMP-66848-Fuca2-B6J-VB
Gene Name
Product ID
S-KO-19478
Gene Alias
0610025O11Rik; 5530401P20Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
10
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fuca2em1/Cya mice (Catalog S-KO-19478) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000121465
NCBI RefSeq
NM_025799
Target Region
Exon 3
Size of Effective Region
~1.6 kb
Detailed Document
Overview of Gene Research
FUCA2, also known as alpha-L-fucosidase 2, is a member of the glycoside hydrolase (GH) families 29A. It is involved in the hydrolysis of terminal L-fucose residues linked to the reducing end of N-acetyl glucosamine (GlcNAc) of oligosaccharide chains, which is related to the defucosylation process influencing various biological processes and disease developments [5].
In cancer research, FUCA2 has emerged as a significant gene. It is upregulated in most tumors and is associated with poor survival rates. For example, in lung cancer cells, knockdown of FUCA2 inhibits cell viability, indicating its oncogene role [1]. In triple-negative breast cancer (TNBC), cancer-associated adipocytes secrete FUCA2 to promote TNBC growth and metastasis through interaction with TM9SF3 [2]. In gastric cancer, FUCA2 expression is markedly increased and is associated with advanced surgical staging and histological grade [3]. In hepatocellular carcinoma, increased FUCA2 expression is related to a poor prognosis and immune infiltration [4]. In lung adenocarcinoma, the FUCA2/GGH axis promotes tumor progression by regulating the cell cycle and epithelial-mesenchymal transition [6].
In conclusion, FUCA2 is mainly associated with cancer progression and prognosis. Its over-expression in various cancers, as revealed by knockdown experiments in cancer cell lines, indicates its oncogenic function. These findings contribute to understanding the role of FUCA2 in cancer development and may provide potential targets for tumor therapy.
References:
1. Zhong, Anyuan, Chen, Ting, Xing, Yufei, Pan, Xue, Shi, Minhua. 2021. FUCA2 Is a Prognostic Biomarker and Correlated With an Immunosuppressive Microenvironment in Pan-Cancer. In Frontiers in immunology, 12, 758648. doi:10.3389/fimmu.2021.758648. https://pubmed.ncbi.nlm.nih.gov/34745134/
2. Liu, Qun, Dong, Hui-Ting, Zhao, Tingting, Jin, Feng, Xing, Peng. 2022. Cancer-associated adipocytes release FUCA2 to promote aggressiveness in TNBC. In Endocrine-related cancer, 29, 139-149. doi:10.1530/ERC-21-0243. https://pubmed.ncbi.nlm.nih.gov/34935631/
3. Leal Quirino, Michael Williames, Albuquerque, Amanda Pinheiro de Barros, de Souza, Maria de Fátima Deodato, Pereira, Michelly Cristiny, de Melo, Moacyr Jesus Barreto. . FUCA2 and TSTA3 expression in gastric cancer: candidate biomarkers of malignant transformation. In Folia histochemica et cytobiologica, 60, 335-343. doi:10.5603/FHC.a2022.0031. https://pubmed.ncbi.nlm.nih.gov/36583336/
4. Hu, Yuanhui, Tang, Dongling, Zhang, Pingan. 2023. Prognostic and immunological role of alpha-L-fucosidase 2 (FUCA2) in hepatocellular carcinoma. In Translational cancer research, 12, 257-272. doi:10.21037/tcr-22-1850. https://pubmed.ncbi.nlm.nih.gov/36915579/
5. Fu, Jinxing, Guo, Qing, Feng, Yuan, Cheng, Peng, Wu, Anhua. 2022. Dual role of fucosidase in cancers and its clinical potential. In Journal of Cancer, 13, 3121-3132. doi:10.7150/jca.75840. https://pubmed.ncbi.nlm.nih.gov/36046653/
6. Peng, Yuanyuan, Yang, Xingyu, Liu, Yafeng, Wu, Jing, Hu, Dong. 2024. The regulation of the cell cycle and epithelial-mesenchymal transition through FUCA2/GGH signaling promotes the progression of lung adenocarcinoma. In Gene, 939, 149183. doi:10.1016/j.gene.2024.149183. https://pubmed.ncbi.nlm.nih.gov/39710011/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen