C57BL/6JCya-D16Ertd472eem1/Cya
Common Name:
D16Ertd472e-KO
Product ID:
S-KO-19506
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
D16Ertd472e-KO
Strain ID
KOCMP-67102-D16Ertd472e-B6J-VB
Gene Name
Product ID
S-KO-19506
Gene Alias
1700010I10Rik; 2310009O17Rik; E330003K22Rik; Eurl
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
16
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-D16Ertd472eem1/Cya mice (Catalog S-KO-19506) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000232052
NCBI RefSeq
NM_001252438
Target Region
Exon 3~5
Size of Effective Region
~3.4 kb
Detailed Document
Overview of Gene Research
D16Ertd472e is a gene that was identified among the differentially alternatively spliced (DAS) genes in a study on hepatic ischemia reperfusion (IR) injury in mice [1]. Its exact function, aliases, associated pathways, and biological importance are not comprehensively detailed in the provided abstract, but its differential splicing was detected, indicating it may play a role in processes related to hepatic IR injury [1].
In the study, high-throughput RNA sequencing and rMATS analysis were used to screen for DAS genes in a mouse model of hepatic IR injury. A total of 898 DAS genes were identified, with D16Ertd472e among them. The expression level of D16Ertd472e was verified by RT-PCR and qRT-PCR, suggesting its significance in the context of hepatic IR injury [1].
In conclusion, D16Ertd472e, as a DAS gene, likely has a role in the molecular mechanisms of hepatic ischemia reperfusion injury in mice. The study of D16Ertd472e in this mouse model contributes to understanding the complex processes involved in hepatic IR injury, potentially providing insights into related disease mechanisms and possible treatment strategies [1].
References：
1. Hua, Yongliang, Li, Xinglong, Yin, Bing, Meng, Zhanzhi, Ma, Yong. 2024. Genome-wide analysis of alternative splicing differences in hepatic ischemia reperfusion injury. In Scientific reports, 14, 31349. doi:10.1038/s41598-024-82846-1. https://pubmed.ncbi.nlm.nih.gov/39732885/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen