C57BL/6JCya-Accslem1/Cya
Common Name:
Accsl-KO
Product ID:
S-KO-19508
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Accsl-KO
Strain ID
KOCMP-381411-Accsl-B6J-VB
Gene Name
Product ID
S-KO-19508
Gene Alias
Gm1967
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Accslem1/Cya mice (Catalog S-KO-19508) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000099690
NCBI RefSeq
NM_001033452
Target Region
Exon 3~4
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
Accsl is one of the hub genes closely related to the occurrence and development of diffuse large B-cell lymphoma (DLBCL) [1]. Through gene-expression and network perturbation analysis of DLBCL patients at different clinical stages, Accsl was identified among key driver genes. The study of its role in DLBCL may help understand the disease progression mechanism.
In this research, gene-expression data of DLBCL patients were analyzed. Weighted gene correlation network analysis and differential module analysis were performed. The thistle1 module was found to be highly related to the clinical stage of DLBCL, and genes in this module were mainly related to the NOD-like receptor signaling pathway, neutrophil activation, etc. Accsl was one of the genes playing a key role in the process [1].
In conclusion, Accsl is a hub gene associated with DLBCL. Its study based on gene-expression analysis helps to understand the molecular mechanism of DLBCL progression, which may provide a basis for the development of new treatment strategies for advanced-stage DLBCL.
References：
1. Xiang, Chenxi, Ni, Huimin, Wang, Zhina, Ma, Dongshen, Liu, Hui. 2021. Agent Repurposing for the Treatment of Advanced Stage Diffuse Large B-Cell Lymphoma Based on Gene Expression and Network Perturbation Analysis. In Frontiers in genetics, 12, 756784. doi:10.3389/fgene.2021.756784. https://pubmed.ncbi.nlm.nih.gov/34721544/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen