Krt78, also known as keratin 78, is likely involved in processes related to keratinization, which is important for the structure and function of epithelial tissues. It may be associated with pathways related to extracellular matrix organization and proteolysis based on its co-differential expression with genes involved in these processes [2].

In head and neck squamous cell carcinoma (HNSCC), Krt78 expression levels correlated with infiltration levels of CD8+ T cells and macrophages, and also with overall survival. Protein expression levels of Krt78 in HNSCC were significantly lower than in normal tissues, suggesting it might be related to the occurrence and development of HNSCC and could serve as a diagnostic and prognostic biomarker [1].

In laryngeal squamous cell carcinoma (LSCC), Krt78 was identified as one of the hub genes through weighted gene co-expression network analysis, indicating its potential importance in this cancer type [4].

In metastatic melanoma, Krt78 was among the hub genes identified through co-expression analysis, suggesting its involvement in the immune response and tumor cell development during tumorigenesis [3].

In conclusion, Krt78 appears to play important roles in multiple cancer-related biological processes, especially in HNSCC, LSCC, and metastatic melanoma. The findings from these studies on Krt78 provide insights into its functions in disease development, which may potentially lead to the development of new diagnostic and prognostic tools as well as targeted therapies for these cancers.