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C57BL/6JCya-Crygcem1/Cya
Common Name:
Crygc-KO
Product ID:
S-KO-19520
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Crygc-KO
Strain ID
KOCMP-12966-Crygc-B6J-VB
Gene Name
Crygc
Product ID
S-KO-19520
Gene Alias
Cryg-5
Background
C57BL/6JCya
NCBI ID
12966
Modification
Conventional knockout
Chromosome
1
Phenotype
MGI:88523
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Crygcem1/Cya mice (Catalog S-KO-19520) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000114064
NCBI RefSeq
NM_001082573
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Crygc, encoding γC-crystallin protein, is crucial for maintaining lens transparency. Mutations in Crygc are associated with congenital cataract, a major cause of childhood blindness. Crystallin proteins contribute to the refractive properties of the lens, and their proper function is essential for normal vision [1-10].

Mouse models have provided valuable insights. For instance, mice with a dominant mutation in Crygc causing cataracts could be rescued by injecting Cas9 mRNA and a single-guide RNA targeting the mutant allele into zygotes. This demonstrated the potential of using the CRISPR-Cas9 system to correct genetic diseases related to Crygc [1]. Additionally, various mutations in Crygc, such as p.Trp131Arg, p.C130fs, p.R48H, p.E128*, etc., have been identified in different human families, expanding the understanding of cataract heterogeneity and the role of Crygc mutations in cataract formation [1, 3-5].

In conclusion, Crygc is essential for maintaining lens transparency, and its mutations are closely associated with congenital cataract. Mouse models, especially those using gene-editing techniques like CRISPR-Cas9, have been instrumental in understanding the role of Crygc in cataract-related diseases and exploring potential treatment strategies.

References:
1. Wu, Yuxuan, Liang, Dan, Wang, Yinghua, Li, Dangsheng, Li, Jinsong. . Correction of a genetic disease in mouse via use of CRISPR-Cas9. In Cell stem cell, 13, 659-62. doi:10.1016/j.stem.2013.10.016. https://pubmed.ncbi.nlm.nih.gov/24315440/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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