C57BL/6JCya-Hsd17b11em1/Cya
Common Name
Hsd17b11-KO
Product ID
S-KO-19583
Backgroud
C57BL/6JCya
Strain ID
KOCMP-114664-Hsd17b11-B6J-VB
When using this mouse strain in a publication, please cite “Hsd17b11-KO Mouse (Catalog S-KO-19583) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Hsd17b11-KO
Strain ID
KOCMP-114664-Hsd17b11-B6J-VB
Gene Name
Product ID
S-KO-19583
Gene Alias
Dhrs8, Pan1b, SDR2, retSDR2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 5
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000031251
NCBI RefSeq
NM_053262
Target Region
Exon 3~4
Size of Effective Region
~2.6 kb
Overview of Gene Research
Hsd17b11, type 11 17β-hydroxysteroid dehydrogenase, catalyzes the conversion of 5α-androstan-3α,17β-diol into androsterone, suggesting its role in androgen metabolism [5]. It may also be involved in lipid metabolism-related pathways as it has been associated with lipid droplets [3]. Additionally, its expression can be regulated by factors like Sp1 and C/EBPα in prostate cancer cells [5].
In various cancers, Hsd17b11 shows different associations. In colorectal cancer, the lnc-HSD17B11-1:1 acts as a ceRNA, sponging miR-338-3p to upregulate MACC1 and promote cancer progression [1]. In lung adenocarcinoma, low expression of Hsd17b11 is related to an increased recurrence rate and affects patient quality of life, and it may be valuable in diagnosis [2]. In pancreatic cancer, Hsd17b11 is among the lipid droplet-associated genes significantly associated with overall survival [3]. In esophageal cancer, m6A demethylase FTO may promote lipid droplet formation by enhancing Hsd17b11 expression, thus promoting cancer development [6]. In breast cancer, high expression of Hsd17b11 is associated with improved relapse-free survival [8]. Also, Hsd17b11 can bio-oxidize certain synthetic antitumor acetylenic lipids, leading to endoplasmic reticulum stress and apoptosis [4,7].
In conclusion, Hsd17b11 is involved in androgen metabolism and lipid-related processes. Its dysregulation is associated with multiple cancers, including colorectal, lung, pancreatic, esophageal, and breast cancers. Understanding Hsd17b11's functions through various research models helps in uncovering the mechanisms of cancer development, potentially providing new targets for cancer diagnosis and treatment.
References：
1. Zhang, Wei, Wang, Bo, Wang, Quan, Jiang, Kewei, Wang, Shan. 2020. Lnc-HSD17B11-1:1 Functions as a Competing Endogenous RNA to Promote Colorectal Cancer Progression by Sponging miR-338-3p to Upregulate MACC1. In Frontiers in genetics, 11, 628. doi:10.3389/fgene.2020.00628. https://pubmed.ncbi.nlm.nih.gov/32595704/
2. Wei, Chunhui, Li, Lixia, Qiao, Youping, Huang, Dan, Wu, Dong. . Ferroptosis-related genes DUOX1 and HSD17B11 affect tumor microenvironment and predict overall survival of lung adenocarcinoma patients. In Medicine, 103, e38322. doi:10.1097/MD.0000000000038322. https://pubmed.ncbi.nlm.nih.gov/39259123/
3. Bai, Rubing, Rebelo, Artur, Kleeff, Jörg, Sunami, Yoshiaki. 2021. Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis. In Lipids in health and disease, 20, 58. doi:10.1186/s12944-021-01476-y. https://pubmed.ncbi.nlm.nih.gov/34078402/
4. Bossuat, Margaux, Rullière, Pauline, Preuilh, Nadège, Britton, Sébastien, Génisson, Yves. 2023. Phenyl dialkynylcarbinols, a Bioinspired Series of Synthetic Antitumor Acetylenic Lipids. In Journal of medicinal chemistry, 66, 13918-13945. doi:10.1021/acs.jmedchem.3c00859. https://pubmed.ncbi.nlm.nih.gov/37816126/
5. Rotinen, Mirja, Villar, Joaquín, Celay, Jon, Notario, Vicente, Encío, Ignacio. 2011. Transcriptional regulation of type 11 17β-hydroxysteroid dehydrogenase expression in prostate cancer cells. In Molecular and cellular endocrinology, 339, 45-53. doi:10.1016/j.mce.2011.03.015. https://pubmed.ncbi.nlm.nih.gov/21549806/
6. Duan, Xiaoran, Yang, Li, Wang, Liuya, Qin, Guohui, Zhang, Yi. 2022. m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer. In Cell & bioscience, 12, 60. doi:10.1186/s13578-022-00798-3. https://pubmed.ncbi.nlm.nih.gov/35568876/
7. Demange, Pascal, Joly, Etienne, Marcoux, Julien, Chauvin, Remi, Britton, Sébastien. 2022. SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species. In eLife, 11, . doi:10.7554/eLife.73913. https://pubmed.ncbi.nlm.nih.gov/35535493/
8. Corbet, Andrea K, Bikorimana, Emmanuel, Boyd, Raya I, Spinella, Michael J, Singh, Ratnakar. 2023. G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells. In Translational oncology, 33, 101676. doi:10.1016/j.tranon.2023.101676. https://pubmed.ncbi.nlm.nih.gov/37086619/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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