C57BL/6JCya-Gfyem1/Cya
Common Name
Gfy-KO
Product ID
S-KO-19588
Backgroud
C57BL/6JCya
Strain ID
KOCMP-100039953-Gfy-B6J-VC
Status
When using this mouse strain in a publication, please cite “Gfy-KO Mouse (Catalog S-KO-19588) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Gfy-KO
Strain ID
KOCMP-100039953-Gfy-B6J-VC
Gene Name
Product ID
S-KO-19588
Gene Alias
Gm581, Goofy, Gm2515
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000179443
NCBI RefSeq
NM_001195255
Target Region
Exon 2~5
Size of Effective Region
~2.8 kb
Overview of Gene Research
Gfy, as identified in various studies, has been associated with multiple biological contexts. In deer mice, it is among candidate genes related to olfaction, potentially playing a role in response to chemical stimuli, which may be related to predator-recognition traits [2].
In Chlamydomonas reinhardtii, genes of the GPR1/FUN34/YaaH (GFY) superfamily, including CrGFY1-5, are suggested to function as intracellular membrane acetate channels, with increased expression upon acetate addition [3].
In a Japanese population study, Gfy was newly identified among 21 genes significantly associated with early-onset coronary artery disease, indicating its potential role in the genetic susceptibility to this condition [1].
In conclusion, Gfy seems to be involved in functions like olfaction, acetate transportation in microalgae, and potentially in the genetic susceptibility to coronary artery disease. The studies in deer mice, microalgae, and the Japanese population contribute to understanding Gfy's diverse biological functions and its implications in different biological systems and disease-related contexts.
References：
1. Yamada, Yoshiji, Yasukochi, Yoshiki, Kato, Kimihiko, Takeuchi, Ichiro, Sakuma, Jun. 2018. Identification of 26 novel loci that confer susceptibility to early-onset coronary artery disease in a Japanese population. In Biomedical reports, 9, 383-404. doi:10.3892/br.2018.1152. https://pubmed.ncbi.nlm.nih.gov/30402224/
2. Orrock, John L, Abueg, Linelle, Gammie, Stephen, Munshi-South, Jason. 2021. Exome sequencing of deer mice on two California Channel Islands identifies potential adaptation to strongly contrasting ecological conditions. In Ecology and evolution, 11, 17191-17201. doi:10.1002/ece3.8357. https://pubmed.ncbi.nlm.nih.gov/34938502/
3. Durante, Lorenzo, Hübner, Wolfgang, Lauersen, Kyle J, Remacle, Claire. 2019. Characterization of the GPR1/FUN34/YaaH protein family in the green microalga Chlamydomonas suggests their role as intracellular membrane acetate channels. In Plant direct, 3, e00148. doi:10.1002/pld3.148. https://pubmed.ncbi.nlm.nih.gov/31245784/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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