C57BL/6JCya-Ffar1em1/Cya
Common Name
Ffar1-KO
Product ID
S-KO-19783
Backgroud
C57BL/6JCya
Strain ID
KOCMP-233081-Ffar1-B6J-VB
Status
When using this mouse strain in a publication, please cite “Ffar1-KO Mouse (Catalog S-KO-19783) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ffar1-KO
Strain ID
KOCMP-233081-Ffar1-B6J-VB
Gene Name
Product ID
S-KO-19783
Gene Alias
Gpr40
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000052700
NCBI RefSeq
NM_194057
Target Region
Exon 1
Size of Effective Region
~1.6 kb
Overview of Gene Research
Ffar1, also known as GPR40, is a G-protein-coupled receptor that functions as a receptor for medium-to long-chain free fatty acids [3,5]. It is involved in glucose-stimulated insulin secretion and incretin production, making it a potential therapeutic target for type 2 diabetes mellitus (T2DM) [1,2,4,6]. Activation of Ffar1 can enhance glucose-dependent insulin secretion without inducing hypoglycemia, and it is also implicated in processes such as inflammation regulation and secretion of peptide hormones [4,5].
In FFAR1 gene-deficient mice, stronger inflammatory and peripheral neuropathic pain-like behavior as well as depressive-like behavior were observed. The findings suggest that FFAR1 indirectly regulates dopamine release by promoting serotonin release, indicating its possible involvement in emotional behaviors [3].
In conclusion, Ffar1 plays a crucial role in glucose metabolism, with its activation being beneficial for T2DM treatment due to its glucose-lowering effect without hypoglycemic risk. The study of Ffar1 knockout mouse models reveals its significance in pain and emotional-related behaviors, providing insights into potential therapeutic applications for CNS disorders and chronic pain in addition to T2DM [3].
References：
1. Ren, Qiang, Fan, Yiqing, Yang, Lixin, Shi, Wei, Qian, Hai. 2023. An updated patent review of GPR40/ FFAR1 modulators (2020 - present). In Expert opinion on therapeutic patents, 33, 565-577. doi:10.1080/13543776.2023.2272649. https://pubmed.ncbi.nlm.nih.gov/37947382/
2. Li, Zheng, Zhou, Zongtao, Zhang, Luyong. 2019. Current status of GPR40/FFAR1 modulators in medicinal chemistry (2016-2019): a patent review. In Expert opinion on therapeutic patents, 30, 27-38. doi:10.1080/13543776.2020.1698546. https://pubmed.ncbi.nlm.nih.gov/31771391/
3. Kurihara, Takashi. . [Possible involvement of FFAR1 signaling in mouse emotional behaviors through the regulation of brain monoamine releases]. In Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 158, 454-459. doi:10.1254/fpj.23054. https://pubmed.ncbi.nlm.nih.gov/37914322/
4. Paul, Abhik, Nahar, Sourin, Nahata, Pankaj, Karmakar, Sanmoy, Maity, Tapan Kumar. 2023. Synthetic GPR40/FFAR1 agonists: An exhaustive survey on the most recent chemical classes and their structure-activity relationships. In European journal of medicinal chemistry, 264, 115990. doi:10.1016/j.ejmech.2023.115990. https://pubmed.ncbi.nlm.nih.gov/38039791/
5. Kimura, Ikuo, Ichimura, Atsuhiko, Ohue-Kitano, Ryuji, Igarashi, Miki. 2019. Free Fatty Acid Receptors in Health and Disease. In Physiological reviews, 100, 171-210. doi:10.1152/physrev.00041.2018. https://pubmed.ncbi.nlm.nih.gov/31487233/
6. Li, Zheng, Xu, Xue, Huang, Wenlong, Qian, Hai. 2017. Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges. In Medicinal research reviews, 38, 381-425. doi:10.1002/med.21441. https://pubmed.ncbi.nlm.nih.gov/28328012/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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