C57BL/6JCya-Mrrfem1/Cya
Common Name:
Mrrf-KO
Product ID:
S-KO-19809
Background:
C57BL/6JCya
Product Type
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Genotype
Sex
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Basic Information
Strain Name
Mrrf-KO
Strain ID
KOCMP-67871-Mrrf-B6J-VB
Gene Name
Product ID
S-KO-19809
Gene Alias
2400002D02Rik; MRFF; MTRRF; RRF
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mrrfem1/Cya mice (Catalog S-KO-19809) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000028250
NCBI RefSeq
NM_026422
Target Region
Exon 4
Size of Effective Region
~1.6 kb
Detailed Document
Overview of Gene Research
Mrrf, the human mitochondrial ribosome recycling factor, is involved in the process of mitochondrial translation [1]. Mitochondrial translation is crucial for the synthesis of proteins essential for mitochondrial function, which in turn impacts overall cellular energy production and various metabolic pathways. Its role in the cell's energy-related processes underscores its biological importance.
No findings from KO/CKO mouse models or other loss-of-function experiments were present in the provided references.
In conclusion, Mrrf plays a significant role in mitochondrial translation, a process vital for maintaining normal cellular function. Although no mouse model-based insights were available, understanding Mrrf's function provides a basis for further exploration of mitochondrial-related biological processes and potentially associated diseases.
References：
1. Hansen, L L, Jørgensen, R, Justesen, J. . Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1-->q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32-->q34.1 with radiation hybrid mapping. In Cytogenetics and cell genetics, 88, 91-2. doi:. https://pubmed.ncbi.nlm.nih.gov/10773675/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen