C57BL/6JCya-Tpgs1em1/Cya
Common Name:
Tpgs1-KO
Product ID:
S-KO-19822
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Tpgs1-KO
Strain ID
KOCMP-110012-Tpgs1-B6J-VC
Gene Name
Product ID
S-KO-19822
Gene Alias
Gm16517; Gtrgeo22; PGs1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
10
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tpgs1em1/Cya mice (Catalog S-KO-19822) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000020552
NCBI RefSeq
NM_148934
Target Region
Exon 1
Size of Effective Region
~0.2 kb
Detailed Document
Overview of Gene Research
Tpgs1, also known as Tubulin polyglutamylase complex1, helps in microtubule polymerization. It is involved in processes like glucose transport, cellular movement, organization of intracellular structure, and intracellular transport [2]. It may also play a role in pathways related to immune synapse formation, TCR signaling, and Wnt signaling regulation [1,5].
In the study of narcolepsy type I, Tpgs1 was among the NT1-specific differentially expressed genes in CD4 T-cell subsets, which are associated with tubulin arrangement and play a role in immune synapse formation and TCR signaling [1]. In a case of polymicrogyria, rare pathological/deleterious variants of Tpgs1 were found among genes involved in the regulation of Wnt signaling, potentially highlighting its contribution to this malformation of cortical development [5]. Also, Tpgs1 was part of the 4-gene signature RISK4LEP that can predict leprosy years before clinical onset [3], and its DNAm at a specific CpG site was associated with body mass index percentile at birth-to-3 years [4].
In summary, Tpgs1 has diverse functions related to microtubule-associated cellular processes. Its role in diseases such as narcolepsy, polymicrogyria, leprosy, and its association with body mass index trajectories showcases its significance in different biological and disease-related contexts. Studies on Tpgs1 contribute to understanding the molecular mechanisms underlying these conditions.
References:
1. Khajavi, Leila, Nguyen, Xuan-Hung, Queriault, Clémence, Zytnicki, Matthias, Liblau, Roland. 2023. The transcriptomics profiling of blood CD4 and CD8 T-cells in narcolepsy type I. In Frontiers in immunology, 14, 1249405. doi:10.3389/fimmu.2023.1249405. https://pubmed.ncbi.nlm.nih.gov/38077397/
2. Taneja, Nancy. . Mass Spectrometric Analysis of Proteins of L6 Skeletal Muscle Cells Under Different Glucose Conditions and Vitamin D Supplementation. In Protein and peptide letters, 25, 356-361. doi:10.2174/0929866525666180406142128. https://pubmed.ncbi.nlm.nih.gov/29623822/
3. Tió-Coma, Maria, Kiełbasa, Szymon M, van den Eeden, Susan J F, Richardus, Jan Hendrik, Geluk, Annemieke. 2021. Blood RNA signature RISK4LEP predicts leprosy years before clinical onset. In EBioMedicine, 68, 103379. doi:10.1016/j.ebiom.2021.103379. https://pubmed.ncbi.nlm.nih.gov/34090257/
4. Yaskolka Meir, Anat, Huang, Wanyu, Cao, Tingyi, Wang, Xiaobin, Liang, Liming. 2023. Umbilical cord DNA methylation is associated with body mass index trajectories from birth to adolescence. In EBioMedicine, 91, 104550. doi:10.1016/j.ebiom.2023.104550. https://pubmed.ncbi.nlm.nih.gov/37088033/
5. Frolov, Andrey, Atwood, Stuart G, Guzman, Miguel A, Martin, John R. 2024. A Rare Case of Polymicrogyria in an Elderly Individual With Unique Polygenic Underlining. In Cureus, 16, e74300. doi:10.7759/cureus.74300. https://pubmed.ncbi.nlm.nih.gov/39717325/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen