Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Pbx3em1/Cya
Common Name:
Pbx3-KO
Product ID:
S-KO-19831
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Pbx3-KO
Strain ID
KOCMP-18516-Pbx3-B6J-VA
Gene Name
Pbx3
Product ID
S-KO-19831
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
18516
Modification
Conventional knockout
Chromosome
2
Phenotype
MGI:97496
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Pbx3em1/Cya mice (Catalog S-KO-19831) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000040638
NCBI RefSeq
NM_016768
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Pbx3, a homeodomain-containing transcription factor of the pre-B cell leukemia (PBX) family, has unique features like forming specific and stable DNA interactions without co-factors. It is extensively involved in early development and some adult processes, and plays crucial roles in cancer-related biological processes [1].

In a murine acute myeloid leukemia (AML) model, Pbx3 was found to be up-regulated by ATP-P2X1-mediated signaling, and it transactivated BCAT1 to maintain the fates of leukemia-initiating cells (LICs). P2X1 knockdown, which decreased Pbx3 levels, inhibited the proliferation of human AML cell lines and primary cells [2].

In colorectal cancer, Pbx3 promoted the pentose phosphate pathway (PPP) by enhancing G6PD expression, thus promoting tumorigenesis both in vitro and in vivo [3].

In glioma, Pbx3 was highly expressed and its expression increased with malignancy. It was an independent influencing factor for poor prognosis of low-grade glioma (LGG) patients and had potential value for early diagnosis and prognosis prediction [4].

In triple-negative breast cancer (TNBC), Pbx3 activated DLG1-AS1, which then promoted TNBC cell proliferation, invasion, and migration by sponging miR-16-5p [5].

In gastric cancer, PBX3 interacted with the SNHG10 promoter to activate its expression, and SNHG10 maintained PBX3 mRNA stability through recruiting DDX54, facilitating cell growth [6].

In breast cancer, leptin activated PBX3 expression in a STAT3-dependent manner, and PBX3 conferred letrozole resistance via transactivation of the FGFR1 signaling [7].

In papillary thyroid carcinoma (PTC), high levels of PBX3 were correlated with tumor size, lymphatic metastasis, TMN stage, and poor prognosis. Overexpression of PBX3 promoted cell proliferation, while its knockdown induced cell cycle arrest, and inhibited angiogenesis and tumor growth in vitro and in vivo [8].

In conclusion, Pbx3 is a multifunctional gene involved in multiple biological processes, especially in cancer development and progression. Studies using various in vivo models, such as mouse models of AML, have revealed its role in promoting cancer cell survival, proliferation, and drug resistance, making it a potential therapeutic target in multiple cancer types.

References:
1. Morgan, Richard, Pandha, Hardev S. 2020. PBX3 in Cancer. In Cancers, 12, . doi:10.3390/cancers12020431. https://pubmed.ncbi.nlm.nih.gov/32069812/
2. He, Xiaoxiao, Xu, Yilu, Huang, Dan, Zhang, Yaping, Zheng, Junke. 2022. P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways. In Leukemia, 37, 265-275. doi:10.1038/s41375-022-01759-y. https://pubmed.ncbi.nlm.nih.gov/36418376/
3. Luo, Xinxin, Wei, Mankun, Li, Wenfang, Kasim, Vivi, Wu, Shourong. 2023. PBX3 promotes pentose phosphate pathway and colorectal cancer progression by enhancing G6PD expression. In International journal of biological sciences, 19, 4525-4538. doi:10.7150/ijbs.86279. https://pubmed.ncbi.nlm.nih.gov/37781025/
4. Pan, Cuicui, Bai, Xueli, Li, Na, Si, Yuanquan, Zhao, Yueran. 2024. PBX3 as a biomarker for the early diagnosis and prediction of prognosis of glioma. In PloS one, 19, e0293647. doi:10.1371/journal.pone.0293647. https://pubmed.ncbi.nlm.nih.gov/38324550/
5. Zhang, Huiming, Shi, Xianquan, Ge, Zhicheng, Xu, Wei, Qu, Xiang. 2022. PBX3-activated DLG1-AS1 can promote the proliferation, invasion, and migration of TNBC cells by sponging miR-16-5p. In Molecular therapy oncolytics, 25, 201-210. doi:10.1016/j.omto.2021.12.023. https://pubmed.ncbi.nlm.nih.gov/35592389/
6. Zhang, Yunfei, Guo, Hongyan, Zhang, Hong. 2020. SNHG10/DDX54/PBX3 Feedback Loop Contributes to Gastric Cancer Cell Growth. In Digestive diseases and sciences, 66, 1875-1884. doi:10.1007/s10620-020-06488-9. https://pubmed.ncbi.nlm.nih.gov/32712782/
7. Pang, Zhi-Yuan, Wei, Yun-Tao, Shang, Mu-Yan, Liu, Xiao-Yan, Zhang, Qiang. 2021. Leptin-elicited PBX3 confers letrozole resistance in breast cancer. In Endocrine-related cancer, , . doi:10.1530/ERC-20-0328. https://pubmed.ncbi.nlm.nih.gov/33608482/
8. Chen, Qin, Yu, Wen-Ying, Zhang, Huan-Huan, Ying, Hua-Zhong, Yu, Chen-Huan. 2020. PBX3 Promotes Tumor Growth and Angiogenesis via Activation of AT1R/VEGFR2 Pathway in Papillary Thyroid Carcinoma. In BioMed research international, 2020, 8954513. doi:10.1155/2020/8954513. https://pubmed.ncbi.nlm.nih.gov/32047817/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest