GRAMD2B, with currently no widely-known common aliases, is a gene whose function is yet to be comprehensively characterized in the provided reference. However, genes in the GRAMD family are often involved in lipid-related cellular processes, and such functions may be relevant to GRAMD2B as well. These processes can be crucial for cell membrane integrity, signaling, and trafficking, which are essential for normal cellular function and overall organismal health. Genetic models, like KO/CKO mouse models, could potentially be used to further explore its function [1].

In a genome-wide association study on coronary artery disease in type 1 diabetes, among the eight suggestive loci (P < 1×10-6), rs2112481 on the GRAMD2B promoter was associated with serum leucocyte concentration [1].

In conclusion, while the full-scope biological functions of GRAMD2B are still being elucidated, the association of the rs2112481 variant on its promoter with serum leucocyte concentration indicates its potential role in immune-related aspects, especially in the context of type 1 diabetes-associated coronary artery disease. The use of genetic models such as KO/CKO mouse models could potentially provide more in-depth insights into its functions in these disease-related processes.