C57BL/6JCya-Col17a1em1/Cya
Common Name
Col17a1-KO
Product ID
S-KO-19898
Backgroud
C57BL/6JCya
Strain ID
KOCMP-12821-Col17a1-B6J-VB
Status
When using this mouse strain in a publication, please cite “Col17a1-KO Mouse (Catalog S-KO-19898) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Col17a1-KO
Strain ID
KOCMP-12821-Col17a1-B6J-VB
Gene Name
Product ID
S-KO-19898
Gene Alias
Bpag, BP180, Bpag2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000026045
NCBI RefSeq
NM_001290825
Target Region
Exon 2
Size of Effective Region
~1.4 kb
Overview of Gene Research
Col17a1, also known as the gene encoding type XVII collagen (COL17A1/BP180), is a critical molecule for hair follicle stem cell (HFSC) maintenance. It is a hemidesmosome component at the epidermal-dermal junction and plays important roles in maintaining the stability between the dermis and epidermis. COL17A1 is involved in multiple biological processes, such as skin homeostasis, epidermal regeneration, and stem cell-related activities [1,2].
In mouse models, DNA damage response in HFSCs causes proteolysis of Col17a1, triggering HFSC aging. Aged HFSCs are cyclically eliminated from the skin, leading to hair follicle miniaturization. The aging process can be recapitulated by Col17a1 deficiency and prevented by forced maintenance of COL17A1 in HFSCs, indicating its key role in the stem-cell-centric aging program of the epithelial mini-organ [1]. Also, stem cells with higher COL17A1 expression outcompete those with lower expression through cell competition in the skin, and loss of COL17A1 limits this competition, causing skin aging [2].
In conclusion, Col17a1 is essential for maintaining skin-related stem cell functions and skin homeostasis. Mouse models with Col17a1 deficiency or forced expression have revealed its significance in hair follicle aging and skin aging processes, providing potential targets for anti-aging therapeutic intervention.
References：
1. Matsumura, Hiroyuki, Mohri, Yasuaki, Binh, Nguyen Thanh, Hoeijmakers, Jan, Nishimura, Emi K. 2016. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. In Science (New York, N.Y.), 351, aad4395. doi:10.1126/science.aad4395. https://pubmed.ncbi.nlm.nih.gov/26912707/
2. Liu, Nan, Matsumura, Hiroyuki, Kato, Tomoki, Nanba, Daisuke, Nishimura, Emi K. 2019. Stem cell competition orchestrates skin homeostasis and ageing. In Nature, 568, 344-350. doi:10.1038/s41586-019-1085-7. https://pubmed.ncbi.nlm.nih.gov/30944469/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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