C57BL/6JCya-4632428C04Rikem1/Cya
Common Name
4632428C04Rik-KO
Product ID
S-KO-19900
Backgroud
C57BL/6JCya
Strain ID
KOCMP-100043102-4632428C04Rik-B6J-VA
Status
When using this mouse strain in a publication, please cite “4632428C04Rik-KO Mouse (Catalog S-KO-19900) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
4632428C04Rik-KO
Strain ID
KOCMP-100043102-4632428C04Rik-B6J-VA
Gene Name
Product ID
S-KO-19900
Gene Alias
Gm4231
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 16
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000181485
NCBI RefSeq
NR_033631
Target Region
Exon 1
Size of Effective Region
~0.5 kb
Overview of Gene Research
4632428C04Rik, also named cardiomyocyte hypertrophic associated inhibitory RNA (CHAIR), is a long noncoding RNA (lncRNA). It has a crucial cardioprotective function, likely through an epigenetic mechanism. It may be involved in the regulatory pathways related to heart development and heart failure [1].
In mouse models, loss-of-function experiments of 4632428C04Rik (KO) showed that while it has no effect on normal hearts, under stress, it leads to accelerated heart function decline, increased hypertrophy, and exacerbated heart failure. In contrast, restoring its expression can rescue the heart from hypertrophy and failure. During heart failure, DNMT3A is recruited to the CHAIR promoter to suppress its expression, and CHAIR interacts with DNMT3A to inhibit its DNA-binding activity [1].
In conclusion, 4632428C04Rik plays a significant cardioprotective role. The KO mouse models have revealed its importance in heart failure, suggesting that it could be a potential target for treating heart failure and related pathological conditions [1].
References：
1. Qian, Yanxia, Zhang, Mingming, Zhou, Ningtian, Ding, Qiang, Wang, Junhong. . A long noncoding RNA CHAIR protects the heart from pathological stress. In Clinical science (London, England : 1979), 134, 1843-1857. doi:10.1042/CS20200149. https://pubmed.ncbi.nlm.nih.gov/32643756/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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