C57BL/6JCya-Sirt7em1/Cya
Common Name:
Sirt7-KO
Product ID:
S-KO-19934
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Sirt7-KO
Strain ID
KOCMP-209011-Sirt7-B6J-VA
Gene Name
Product ID
S-KO-19934
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
11
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Sirt7em1/Cya mice (Catalog S-KO-19934) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000080202
NCBI RefSeq
NM_153056
Target Region
Exon 4~9
Size of Effective Region
~2.8 kb
Detailed Document
Overview of Gene Research
SIRT7, a member of the sirtuin family, is an NAD+-dependent lysine deacetylase and deacylase. It plays crucial roles in diverse biological processes, including metabolism, stress responses, and aging [1,2,5]. SIRT7 is involved in pathways such as glucose and lipid metabolism, DNA damage repair, and ribosomal RNA expression [1,2,4]. Genetic models, like KO/CKO mouse models, have been valuable in studying its functions.
In mice, loss of Sirt7 impedes the hair follicle life-cycle transition from telogen to anagen phase, delaying hair growth, while its overexpression accelerates this process. Mechanistically, Sirt7 interacts with and deacetylates Nfatc1, leading to its degradation and promoting anagen entry [3]. In pulmonary hypertension, SIRT7 levels are reduced. Pulmonary endothelium-specific depletion of Sirt7 exacerbates the disease, while its overexpression reverses the phenotypes by deacetylating KLF4 and maintaining pulmonary arterial endothelium cell (PAEC) homeostasis [6].
In conclusion, SIRT7 is essential for processes like hair growth and maintaining PAEC homeostasis. Mouse KO/CKO models have revealed its significance in diseases such as hair growth disorders and pulmonary hypertension, providing insights into potential therapeutic strategies targeting SIRT7 in these conditions.
References:
1. Yamagata, Kazuya, Mizumoto, Tomoya, Yoshizawa, Tatsuya. 2023. The Emerging Role of SIRT7 in Glucose and Lipid Metabolism. In Cells, 13, . doi:10.3390/cells13010048. https://pubmed.ncbi.nlm.nih.gov/38201252/
2. Lagunas-Rangel, Francisco Alejandro. 2022. SIRT7 in the aging process. In Cellular and molecular life sciences : CMLS, 79, 297. doi:10.1007/s00018-022-04342-x. https://pubmed.ncbi.nlm.nih.gov/35585284/
3. Li, Guo, Tang, Xiaolong, Zhang, Shuping, Li, Ji, Liu, Baohua. 2020. SIRT7 activates quiescent hair follicle stem cells to ensure hair growth in mice. In The EMBO journal, 39, e104365. doi:10.15252/embj.2019104365. https://pubmed.ncbi.nlm.nih.gov/32696520/
4. Tang, Ming, Tang, Huangqi, Tu, Bo, Zhu, Wei-Guo. 2021. SIRT7: a sentinel of genome stability. In Open biology, 11, 210047. doi:10.1098/rsob.210047. https://pubmed.ncbi.nlm.nih.gov/34129782/
5. Raza, Umar, Tang, Xiaolong, Liu, Zuojun, Liu, Baohua. 2023. SIRT7: the seventh key to unlocking the mystery of aging. In Physiological reviews, 104, 253-280. doi:10.1152/physrev.00044.2022. https://pubmed.ncbi.nlm.nih.gov/37676263/
6. Zhang, Jin, Xu, Chenzhong, Tang, Xiaolong, Shyy, John Y J, Liu, Baohua. . Endothelium-specific SIRT7 targeting ameliorates pulmonary hypertension through Krüpple-like factor 4 deacetylation. In Cardiovascular research, 120, 403-416. doi:10.1093/cvr/cvae011. https://pubmed.ncbi.nlm.nih.gov/38198357/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen